Duah Maxwell, Zhang Kexin, Liang Yiwen, Ayarick Vivian Adiila, Xu Kailin, Pan Bin
Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, Jiangsu, China; Department of Hematology, Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Pathophysiology, Institute for Cancer Research, School of Basic Medical Science, Xi'an Jiaotong University, Xi'an, Shanxi, China.
J Nutr Biochem. 2023 Feb;112:109222. doi: 10.1016/j.jnutbio.2022.109222. Epub 2022 Nov 17.
Fatty acid metabolism contributes to energy supply and plays an important role in regulating immunity. Free fatty acids (FFAs) bind to free fatty acid receptors (FFARs) on the cell surface and mediate effects through the intra-cellular FFAR signaling pathways. FFAR4, also known as G-protein coupled receptor 120 (GPR120), has been identified as the primary receptor of omega-3 polyunsaturated fatty acids (ω-3 PUFAs). FFAR4 is a promising target for treating metabolic and inflammatory disorders due to its immune regulatory functions and the discovery of highly selective and efficient agonists. This review summarizes the reported immune regulatory functions of ω-3 PUFAs and FFAR4 in immune cells and immune-related diseases. We also speculate possible involvements of ω-3 PUFAs and FFAR4 in other types of inflammatory disorders.
脂肪酸代谢有助于能量供应，并在调节免疫方面发挥重要作用。游离脂肪酸（FFAs）与细胞表面的游离脂肪酸受体（FFARs）结合，并通过细胞内FFAR信号通路介导效应。FFAR4，也称为G蛋白偶联受体120（GPR120），已被确定为ω-3多不饱和脂肪酸（ω-3 PUFAs）的主要受体。由于其免疫调节功能以及高选择性和高效激动剂的发现，FFAR4是治疗代谢和炎症性疾病的一个有前景的靶点。本综述总结了ω-3 PUFAs和FFAR4在免疫细胞和免疫相关疾病中已报道的免疫调节功能。我们还推测了ω-3 PUFAs和FFAR4在其他类型炎症性疾病中的可能参与情况。
