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必需脂肪酸(EFAs)能否预防和改善新冠后长期症状?

Can essential fatty acids (EFAs) prevent and ameliorate post-COVID-19 long haul manifestations?

机构信息

UND Life Sciences, 2221 NW 5th St, Battle ground, WA, 98604, USA.

Department of Biotechnology, Indian Institute of Technology-Hyderabad, Sangareddy, Telangana, India.

出版信息

Lipids Health Dis. 2024 Apr 19;23(1):112. doi: 10.1186/s12944-024-02090-4.

Abstract

It is hypothesized that COVID-19, post-COVID and post-mRNA COVID-19 (and other related) vaccine manifestations including "long haul syndrome" are due to deficiency of essential fatty acids (EFAs) and dysregulation of their metabolism. This proposal is based on the observation that EFAs and their metabolites can modulate the swift immunostimulatory response of SARS-CoV-2 and similar enveloped viruses, suppress inappropriate cytokine release, possess cytoprotective action, modulate serotonin and bradykinin production and other neurotransmitters, inhibit NF-kB activation, regulate cGAS-STING pathway, modulate gut microbiota, inhibit platelet activation, regulate macrophage and leukocyte function, enhance wound healing and facilitate tissue regeneration and restore homeostasis. This implies that administration of EFAs could be of benefit in the prevention and management of COVID-19 and its associated complications.

摘要

据推测,COVID-19、COVID 后和 mRNA COVID-19(和其他相关)疫苗表现包括“长途跋涉综合征”是由于必需脂肪酸(EFAs)的缺乏和它们的代谢失调。这一建议是基于这样的观察,即 EFAs 和它们的代谢物可以调节 SARS-CoV-2 和类似包膜病毒的迅速免疫刺激反应,抑制不适当的细胞因子释放,具有细胞保护作用,调节血清素和缓激肽的产生和其他神经递质,抑制 NF-kB 激活,调节 cGAS-STING 途径,调节肠道微生物群,抑制血小板激活,调节巨噬细胞和白细胞功能,增强伤口愈合,促进组织再生和恢复体内平衡。这意味着 EFAs 的给药可能有益于 COVID-19 及其相关并发症的预防和管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c233/11027247/95295c22b36a/12944_2024_2090_Fig1_HTML.jpg

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