Department of Pediatrics, Division of Environmental Pediatrics, NYU Grossman School of Medicine, New York, NY, USA; Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA; Department of Environmental Medicine, NYU Grossman School of Medicine, New York, NY, USA; NYU Wagner School of Public Service, New York, NY, USA; NYU School of Global Public Health, New York, NY, USA.
Institute of Environmental Health Sciences and Department of Pharmacology, Wayne State University, Detroit, MI, USA.
Pediatr Clin North Am. 2023 Feb;70(1):137-150. doi: 10.1016/j.pcl.2022.09.003.
Children suffer disproportionately from disease and disability due to environmental hazards, for reasons rooted in their biology. The contribution is substantial and increasingly recognized, particularly due to ever-increasing awareness of endocrine disruption. Regulatory actions can be traced directly to reductions in toxic exposures, with tangible benefits to society. Deep flaws remain in the policy framework in industrialized countries, failing to offer sufficient protection, but are even more limited in industrializing nations where the majority of chemical production and use will occur by 2030. Evidence-based steps for reducing chemical exposures associated with adverse health outcomes exist and should be incorporated into anticipatory guidance.
儿童由于环境危害而不成比例地遭受疾病和残疾,其原因根植于他们的生物学特性。这一贡献是巨大的,而且越来越受到认可,特别是由于人们对内分泌干扰的认识不断提高。监管行动可以直接追溯到减少有毒物质暴露,从而为社会带来实实在在的好处。在工业化国家,政策框架仍然存在严重缺陷,未能提供充分的保护,而在发展中国家,这种缺陷更为有限,到 2030 年,大多数化学品的生产和使用将发生在这些国家。存在减少与不良健康结果相关的化学物质暴露的循证措施,应将其纳入预期指导。