前列腺癌患者前列腺周围脂肪组织中持久性有机氯农药的残留：种族地理差异与疾病侵袭性的关系。

Persistent organochlorine pesticides in periprostatic adipose tissue from men with prostate cancer: Ethno-geographic variations, association with disease aggressiveness.

机构信息

Oniris, INRAE, LABERCA, 44300, Nantes, France.

Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 bd Tonnellé, 37032, Tours, France.

出版信息

Environ Res. 2023 Jan 1;216(Pt 4):114809. doi: 10.1016/j.envres.2022.114809. Epub 2022 Nov 17.

DOI:10.1016/j.envres.2022.114809

PMID:36403647

Abstract

Although several studies have examined the relationship between organochlorine pesticides (OCPs) and prostate cancer (PCa) risk, no data are available concerning the association between OCPs concentrations in periprostatic adipose tissue (PPAT), which reflects cumulative exposure, and PCa aggressiveness. Moreover, no previous study has compared OCPs exposure in two distinct ethno-geographical populations. The objectives were to analyze OCPs in PPAT of PCa patients from either Mainland France or French West Indies in correlation with features of tumor aggressiveness, after adjusting for potential confounders such age, BMI, and polyunsaturated fatty acid (PUFA) content of PPAT. PPAT was analyzed in 160 patients (110 Caucasians and 50 African-Caribbeans), 80 with an indolent tumor (ISUP group 1 + pT2), and 80 with an aggressive tumor (ISUP group more than 3 + pT3). The concentrations of 29 OCPs were measured in PPAT concomitantly with the characterization of PUFA content. Exposure patterns of OCPs differed according to the ethno-geographical origin. Most OCPs were found at higher concentration in Caucasian patients, whereas pp'-DDE content was twice as high in African-Caribbeans. Chlordecone was only detected in PPAT from African-Caribbean patients. Most OCP concentrations were positively correlated with age, and some with BMI. After adjusting for age, BMI, and PUFA composition of PPAT, no significant association was found between OCPs content and risk of aggressive disease, except of mirex which appeared inversely associated with aggressive features of PCa in Caucasian patients. These results highlight a significant ethno-geographic variation in internal exposure to OCPs, which likely reflects differences in consumption patterns. The inverse relationship observed between mirex concentration and markers of PCa aggressiveness need to be further investigated.

摘要

尽管有几项研究探讨了有机氯农药（OCPs）与前列腺癌（PCa）风险之间的关系，但目前尚无有关反映累积暴露的前列腺周围脂肪组织（PPAT）中 OCP 浓度与 PCa 侵袭性之间关系的数据。此外，以前没有研究比较过来自法国大陆或法属西印度群岛的两个不同种族群体的 OCP 暴露情况。本研究的目的是分析来自法国大陆或法属西印度群岛的 PCa 患者的 PPAT 中的 OCPs，并将其与肿瘤侵袭性的特征相关联，同时调整了潜在的混杂因素，如年龄、BMI 和 PPAT 中多不饱和脂肪酸（PUFA）的含量。共分析了 160 名患者（110 名白人和 50 名非洲加勒比人）的 PPAT，其中 80 名患者肿瘤惰性（ISUP 组 1+pT2），80 名患者肿瘤侵袭性强（ISUP 组大于 3+pT3）。同时测定了 PPAT 中 29 种 OCP 的浓度，并对 PUFA 含量进行了特征描述。OCP 的暴露模式因种族起源的不同而有所差异。在白种人患者中，大多数 OCP 的浓度较高，而 pp'-DDE 的含量在非洲加勒比人患者中则是两倍。仅在来自非洲加勒比人患者的 PPAT 中检测到了十氯酮。大多数 OCP 浓度与年龄呈正相关，而与 BMI 相关的一些浓度则呈正相关。在调整了年龄、BMI 和 PPAT 中 PUFA 组成后，除了 mirex 之外，OCP 含量与侵袭性疾病的风险之间没有显著关联，mirex 在白种人患者中与 PCa 的侵袭性特征呈负相关。这些结果突出表明，OCP 内暴露量存在显著的种族地理差异，这可能反映了消费模式的差异。需要进一步研究 mirex 浓度与 PCa 侵袭性标志物之间的这种反比关系。