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长时间的晨僵在手部骨关节炎中很常见,且不排除手部骨关节炎的诊断。

Prolonged morning stiffness is common in hand OA and does not preclude a diagnosis of hand osteoarthritis.

作者信息

van de Stadt L A, Haugen I K, Felson D, Kloppenburg M

机构信息

Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.

Center of Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway.

出版信息

Osteoarthritis Cartilage. 2023 Apr;31(4):529-533. doi: 10.1016/j.joca.2022.10.022. Epub 2022 Nov 18.

Abstract

OBJECTIVE

Prolonged morning stiffness (>60 min) is considered a symptom of inflammatory arthritis, but has a poor discriminative ability. Knowledge about morning stiffness in patients with hand osteoarthritis (OA) is lacking. We therefore studied morning stiffness in patients with hand OA.

DESIGN

Patients with primary hand OA according to their treating rheumatologist in the Hand OSTeoArthritis in Secondary care (HOSTAS) cohort were studied. Severity of morning stiffness was examined with Australian/Canadian hand OA index (AUSCAN) and presence and duration of morning stiffness were examined with a standardized questionnaire. Association of patient and disease characteristics with prolonged morning stiffness (>60 min) were analyzed with logistic regression.

RESULTS

In total 519 of 538 patients had available data about duration of morning stiffness, of whom 89 (17%) had prolonged morning stiffness. Severity of stiffness was mild in 158 of 525 (30%), intermediate in 194 (37%), severe in 97 (18%) and extreme in 19 (4%) patients. Patients with prolonged morning stiffness reported more pain, worse physical function and had a reduced mental and physical quality of life. Patients with prolonged morning stiffness also had more severe radiographic disease, although the association did not reach statistical significance.

CONCLUSIONS

Prolonged and severe morning stiffness are frequently present in patients with hand OA. Patients with these symptoms report more pain in general and have a lower quality of life than patients that do not report these symptoms. Prolonged morning stiffness does not preclude a diagnosis of hand OA.

摘要

目的

长时间晨僵(>60分钟)被认为是炎症性关节炎的症状,但鉴别能力较差。目前缺乏关于手部骨关节炎(OA)患者晨僵的相关知识。因此,我们对手部OA患者的晨僵情况进行了研究。

设计

对二级医疗手部骨关节炎(HOSTAS)队列中经治疗的风湿病专家诊断为原发性手部OA的患者进行研究。采用澳大利亚/加拿大手部OA指数(AUSCAN)检查晨僵的严重程度,并用标准化问卷检查晨僵的存在情况和持续时间。采用逻辑回归分析患者及疾病特征与长时间晨僵(>60分钟)的相关性。

结果

538例患者中有519例有晨僵持续时间的可用数据,其中89例(17%)存在长时间晨僵。525例患者中,158例(30%)的僵硬程度为轻度,194例(37%)为中度,97例(18%)为重度,19例(4%)为极重度。存在长时间晨僵的患者报告有更多疼痛、更差的身体功能,且心理和身体生活质量下降。存在长时间晨僵的患者影像学疾病也更严重,尽管这种关联未达到统计学意义。

结论

手部OA患者常出现长时间和严重的晨僵。有这些症状的患者总体上报告有更多疼痛,且生活质量低于无这些症状的患者。长时间晨僵并不排除手部OA的诊断。

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