Hoseini Tavassol Zahra, Mousavi Seyed Mohammad, Molaei Bahareh, Bandarian Fatemeh, Ejtahed Hanieh-Sadat, Khalagi Kazem, Ghannadi Shima, Larijani Bagher, Hasani-Ranjbar Shirin
Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
J Diabetes Metab Disord. 2022 Oct 24;21(2):1975-1989. doi: 10.1007/s40200-022-01139-4. eCollection 2022 Dec.
Single nucleotide polymorphisms have been implicated in various diseases, most notably non-communicable diseases (NCDs). The aim of this study was to review available evidence regarding associations between polymorphisms and NCDs in the Iranian population.
A comprehensive search was conducted through PubMed/Medline and Scopus databases up to December 2021, as well as reference lists of pertinent articles and key journals. All observational studies that examined the association between gene polymorphisms and NCDs in the Iranian population were included. There was no limitation on the publication year. The Newcastle-Ottawa Scale (NOS) was used to assess the study's quality.
The initial search yielded 95 studies, of which 30 studies were included in the current systematic review. The underlying disorders were obesity, type 2 diabetes, breast and colorectal cancers, depression, and metabolic syndrome. These studies found an association between gene polymorphisms and obesity in the Iranian population, but the relationship with other NCDs was debatable. Even though, other diseases such as diabetes and metabolic syndrome, which are closely related to obesity, may also be associated with gene polymorphisms.
gene polymorphism appears to play a role in the occurrence of NCDs. Some of the study results may be misleading due to ethnic differences and the effect of other genetic factors on disease onset, which needs to be investigated further. Finally, gene polymorphisms can be studied as a preventive or therapeutic target.
The online version contains supplementary material available at 10.1007/s40200-022-01139-4.
单核苷酸多态性与多种疾病有关，尤其是非传染性疾病（NCDs）。本研究的目的是综述伊朗人群中多态性与非传染性疾病之间关联的现有证据。
截至2021年12月，通过PubMed/Medline和Scopus数据库进行了全面检索，并检索了相关文章和关键期刊的参考文献列表。纳入了所有研究伊朗人群基因多态性与非传染性疾病之间关联的观察性研究。对发表年份没有限制。使用纽卡斯尔-渥太华量表（NOS）评估研究质量。
初步检索得到95项研究，其中30项研究纳入了当前的系统评价。潜在疾病包括肥胖、2型糖尿病、乳腺癌和结直肠癌、抑郁症和代谢综合征。这些研究发现伊朗人群中基因多态性与肥胖之间存在关联，但与其他非传染性疾病的关系存在争议。尽管如此，其他与肥胖密切相关的疾病，如糖尿病和代谢综合征，也可能与基因多态性有关。
基因多态性似乎在非传染性疾病的发生中起作用。由于种族差异和其他遗传因素对疾病发病的影响，一些研究结果可能会产生误导，需要进一步研究。最后，基因多态性可作为预防或治疗靶点进行研究。
在线版本包含可在10.1007/s40200-022-01139-4获取的补充材料。
