Association of fat mass and obesity-associated () gene polymorphisms with non-communicable diseases (NCDs) in the Iranian population: A systematic review of observational studies.

BACKGROUND

Single nucleotide polymorphisms have been implicated in various diseases, most notably non-communicable diseases (NCDs). The aim of this study was to review available evidence regarding associations between polymorphisms and NCDs in the Iranian population.

METHODS

A comprehensive search was conducted through PubMed/Medline and Scopus databases up to December 2021, as well as reference lists of pertinent articles and key journals. All observational studies that examined the association between gene polymorphisms and NCDs in the Iranian population were included. There was no limitation on the publication year. The Newcastle-Ottawa Scale (NOS) was used to assess the study's quality.

RESULTS

The initial search yielded 95 studies, of which 30 studies were included in the current systematic review. The underlying disorders were obesity, type 2 diabetes, breast and colorectal cancers, depression, and metabolic syndrome. These studies found an association between gene polymorphisms and obesity in the Iranian population, but the relationship with other NCDs was debatable. Even though, other diseases such as diabetes and metabolic syndrome, which are closely related to obesity, may also be associated with gene polymorphisms.

CONCLUSION

gene polymorphism appears to play a role in the occurrence of NCDs. Some of the study results may be misleading due to ethnic differences and the effect of other genetic factors on disease onset, which needs to be investigated further. Finally, gene polymorphisms can be studied as a preventive or therapeutic target.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s40200-022-01139-4.