Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Spain; Institute of Neurosciences 'Federico Olóriz', Biomedical Research Centre (CIBM), University of Granada, Spain.
Institute of Neurosciences 'Federico Olóriz', Biomedical Research Centre (CIBM), University of Granada, Spain; Department of Nursing, Faculty of Health Sciences, University of Granada, Spain.
Neurosci Biobehav Rev. 2021 Aug;127:630-637. doi: 10.1016/j.neubiorev.2021.05.013. Epub 2021 May 19.
Depression and obesity are major global health problems that frequently co-occur. The FTO gene has one of the strongest links with obesity and high body mass index (BMI) in humans. Besides, this gene is highly expressed in the brain, may play a role in the nervous system, and could confer risk for depression, although scarce literature is available in this respect. We perform a systematic review of the relationship between FTO and both conditions. We selected original articles with observational design or reviews, where depression was assessed with ICD-10, DSM-5 or previous versions, published from 2012 (when the first related paper was published) to November 2020, performed in adults, in English or Spanish and having an optimal methodological quality (evaluated with SIGN checklist). Five original studies were finally included. The results regarding the role of FTO in depression-obesity comorbidity were inconclusive. This leads us to endorse further research covering the role of this gene on both conditions, emphasising a more precise characterization of depression, in order to confirm this role.
抑郁和肥胖是全球主要的健康问题，两者经常同时出现。FTO 基因与肥胖和人体质量指数（BMI）的关联性最强。此外，该基因在大脑中高度表达，可能在神经系统中发挥作用，并可能导致抑郁，尽管这方面的文献很少。我们对 FTO 与这两种情况之间的关系进行了系统评价。我们选择了具有观察性设计或综述的原始文章，其中抑郁的评估使用了 ICD-10、DSM-5 或以前的版本，发表时间从 2012 年（第一份相关论文发表的时间）到 2020 年 11 月，研究对象为成年人，语言为英语或西班牙语，具有最佳的方法学质量（使用 SIGN 清单进行评估）。最后纳入了五项原始研究。关于 FTO 在抑郁-肥胖共病中的作用的结果尚无定论。这使我们支持进一步的研究，涵盖该基因在这两种情况中的作用，强调更精确地描述抑郁，以确认这种作用。
