De Mandal Surajit, Jeon Junhyun
Department of Biotechnology, College of Life and Applied Sciences, Yeungnam University, Gyeongsan, Korea.
Plant Immunity Research Center, Seoul National University, Seoul, Korea.
Mycobiology. 2022 Sep 20;50(5):259-268. doi: 10.1080/12298093.2022.2118928. eCollection 2022.
The nuclear import of proteins is a fundamental process in the eukaryotes including plant. It has become evident that such basic process is exploited by nuclear effectors that contain nuclear localization signal (NLS) and are secreted into host cells by fungal pathogens of plants. However, only a handful of nuclear effectors have been known and characterized to date. Here, we first summarize the types of NLSs and prediction tools available, and then delineate examples of fungal nuclear effectors and their roles in pathogenesis. Based on the knowledge on NLSs and what has been gleaned from the known nuclear effectors, we point out the gaps in our understanding of fungal nuclear effectors that need to be filled in the future researches.
蛋白质的核输入是包括植物在内的真核生物中的一个基本过程。很明显，含有核定位信号（NLS）并被植物真菌病原体分泌到宿主细胞中的核效应子利用了这一基本过程。然而，迄今为止，只有少数核效应子为人所知并得到了表征。在这里，我们首先总结了NLS的类型和可用的预测工具，然后描述了真菌核效应子的例子及其在发病机制中的作用。基于对NLS的了解以及从已知核效应子中收集到的信息，我们指出了在未来研究中需要填补的我们对真菌核效应子理解上的空白。
