Heijmans F, Bert J, Pinder K
Comput Methods Programs Biomed. 1986 Oct;23(2):93-101. doi: 10.1016/0169-2607(86)90104-5.
A validated computer simulation of pulmonary microvascular exchange (J.L. Bert and K.L. Pinder, Microvasc. Res., 27 (1984) 51-70) has been extended to include exchange with the air space (alveoli). Equations which hypothetically describe characteristics associated with this additional compartment and the exchange of both fluid and plasma proteins between the lung tissue and the alveolar space are presented. These are incorporated into the simulation which has been used to predict the behavior of the pulmonary microvascular exchange system including alveolar flooding. The predicted trends associated with alveolar flooding are reasonable. However, due to the lack of specific experimental or clinical findings, the simulation remains essentially unvalidated. The effect on alveolar flooding and interstitial edema of the parameters associated with the additional relationships is presented and discussed. Primarily, results for perturbations in circulatory pressure are presented. Additionally, changes in permeability characteristics are shown and discussed.
一种经过验证的肺微血管交换计算机模拟（J.L. 伯特和K.L. 平德，《微血管研究》，27 (1984) 51 - 70）已得到扩展，以纳入与气腔（肺泡）的交换。文中给出了一些方程，这些方程假设性地描述了与这个额外腔室相关的特征以及肺组织与肺泡空间之间液体和血浆蛋白的交换。这些方程被纳入模拟中，该模拟已被用于预测肺微血管交换系统包括肺泡灌洗的行为。与肺泡灌洗相关的预测趋势是合理的。然而，由于缺乏具体的实验或临床发现，该模拟基本上仍未得到验证。文中呈现并讨论了与这些额外关系相关的参数对肺泡灌洗和间质水肿的影响。主要呈现了循环压力扰动的结果。此外，还展示并讨论了通透性特征的变化。
