Shahid Muhammad Nabeel, Afzal Hassaan Shahzad, Farooq Bareerah, Yousaf Muhammad Rehan, Ijaz Muhammad Rauf, Shafqat Talha Ali, Khan Tahir Mehmood, Neoh Chin Fen, Lean Qi Ying, Bukhsh Allah, Karuppannan Mahmathi
Department of Pharmacy Practice, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Cawangan Selangor, Puncak Alam Campus, Shah Alam, Malaysia.
Department of Pharmacy Practice, Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan.
Front Physiol. 2022 Nov 4;13:930676. doi: 10.3389/fphys.2022.930676. eCollection 2022.
Male infertility is an emerging health issue in the world today. Surgical interventions for the treatment of male infertility are available but are quite expensive. Herbal interventions pose a popular alternative for the treatment of infertility. However, much has to be learned regarding their safety and efficacy. The aim of the study was to investigate the efficacy of herbal interventions in male infertility and also assess the possibility of these interventions as complementary and alternative medicine (CAM) in the future. From inception until 16 December 2021, all articles emphasizing the efficacy of herbal interventions in the treatment of male infertility are included in this review. Seven databases are searched. The literature obtained is screened and extracted. Semen parameters, hormonal concentration, and conception are the outcomes of interest. A total of 19 articles were included in this review. Herbal interventions might improve semen parameters in males with infertility. Among all the interventions, Hochu-ekki-to and have shown the most promising results and should be studied further in a larger sample size. This systematic review has demonstrated the efficacy of herbal interventions, especially Hochu-ekki-to and , in treating male infertility.
男性不育是当今世界一个新出现的健康问题。有针对男性不育的手术干预措施，但费用相当昂贵。草药干预是治疗不育症的一种流行替代方法。然而，关于它们的安全性和有效性仍有很多需要了解的地方。本研究的目的是调查草药干预对男性不育的疗效，并评估这些干预措施在未来作为补充和替代医学（CAM）的可能性。从开始到2021年12月16日，所有强调草药干预对男性不育治疗疗效的文章都纳入了本综述。检索了七个数据库。对获得的文献进行筛选和提取。精液参数、激素浓度和受孕情况是感兴趣的结果。本综述共纳入19篇文章。草药干预可能会改善不育男性的精液参数。在所有干预措施中，补中益气汤和……显示出最有前景的结果，应在更大样本量中进一步研究。本系统综述证明了草药干预，尤其是补中益气汤和……，在治疗男性不育方面的疗效。
