Fuyang People's Hospital, Anhui Medical University, Fuyang, China.
Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Andrology. 2020 Sep;8(5):1038-1050. doi: 10.1111/andr.12787. Epub 2020 Mar 31.
Male infertility is a tough problem in medicine. This article aims to provide the latest evidence for the efficacy and safety of traditional Chinese medicine (TCM) combined with vitamins in the treatment of male infertility.
All randomized controlled trials (RCTs) that used TCM combined with vitamins for male infertility treatment were included in databases of China National Knowledge Infrastructure (CNKI), Wanfang, VIP Database, China Biology Medicine disc (CBM), MEDLINE, EMBASE, and Cochrane Library. The quality of the included articles was evaluated using the Cochrane Reviewer's Handbook 5.3, and meta-analysis was performed using Stata 15.
A total of 14 eligible studies with 1488 patients were included in this meta-analysis. The results suggested that, compared with vitamin E or vitamin E + C alone, combination of TCM with vitamins increased significantly sperm concentration, sperm motility, sperm viability, liquefaction time of semen, the activity of acrosome enzyme, and the pregnancy rate of patients with male infertility. Three kinds of TCM (Shengjing capsule, Huanshao capsule, and compound Xuanju capsule) showed significant improvement for male infertility in terms of pregnancy rate, sperm concentration, or sperm motility. In addition, the results of the publication bias test demonstrated that no significant bias occurred.
Traditional Chinese medicine combined with vitamins has significant efficacy in the treatment of male infertility with no increase in side effects. The specific implementing regulations still need more long-term, multicenter, randomized, and double-blind clinical trials.
男性不育是医学上的一个难题。本文旨在为中药（TCM）联合维生素治疗男性不育的疗效和安全性提供最新证据。
纳入中国知网（CNKI）、万方、维普数据库、中国生物医学文献数据库（CBM）、MEDLINE、EMBASE 和 Cochrane Library 中所有采用 TCM 联合维生素治疗男性不育的随机对照试验（RCT）。使用 Cochrane 评论员手册 5.3 评估纳入文章的质量，并使用 Stata 15 进行荟萃分析。
本荟萃分析共纳入 14 项符合条件的研究，共 1488 例患者。结果表明，与维生素 E 或维生素 E+C 单独治疗相比，TCM 联合维生素治疗可显著提高精子浓度、精子活力、精子活力、精液液化时间、顶体酶活性和男性不育患者的妊娠率。三种 TCM（生精胶囊、焕少胶囊和复方玄驹胶囊）在妊娠率、精子浓度或精子活力方面对男性不育均有显著改善作用。此外，发表偏倚检验结果表明无显著偏倚。
中药联合维生素治疗男性不育具有显著疗效，且无副作用增加。具体实施细则仍需更多长期、多中心、随机、双盲的临床试验。
