Khan Abed H, Rahaman Mohammad Ferdous Ur, Rahman Sadia, Rahman Khan Mizanur, Sami Chowdhury Adnan
Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, BGD.
Cureus. 2022 Oct 15;14(10):e30323. doi: 10.7759/cureus.30323. eCollection 2022 Oct.
Castleman disease (CD), a heterogenous lymphoproliferative disorder resulting from immune dysregulation, is a very rare disease in clinical practice. The clinical spectrum of Castleman disease is wide and its treatment options are mostly based on case reports and case series. To date, two clinical and four histological types have been described. It has recently been successfully demonstrated that the pathogenesis of multicentric Castleman disease (MCD) has a direct association with human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8) infection which is why further studies are necessary. Here, we report an unusual case of MCD not associated with HIV and having a histological diagnosis of the hyaline vascular type that presented with acute renal impairment and subcutaneous abnormal lymphatic proliferation.
卡斯特尔曼病（CD）是一种由免疫失调引起的异质性淋巴增生性疾病，在临床实践中非常罕见。卡斯特尔曼病的临床谱广泛，其治疗方案大多基于病例报告和病例系列。迄今为止，已描述了两种临床类型和四种组织学类型。最近已成功证明，多中心卡斯特尔曼病（MCD）的发病机制与人类免疫缺陷病毒（HIV）和人类疱疹病毒8（HHV-8）感染直接相关，这就是需要进一步研究的原因。在此，我们报告一例罕见的MCD病例，该病例与HIV无关，组织学诊断为透明血管型，表现为急性肾功能损害和皮下异常淋巴增生。
