Department of Obstetrics and Gynecology of West China Second University Hospital, BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, China.
Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2022 Nov 2;13:1035338. doi: 10.3389/fendo.2022.1035338. eCollection 2022.
Abnormal spermatozoa can not only reduce the fertilization rate, but also prolong the natural conception time and even increase the risk of spontaneous miscarriage. Diabetes mellitus (DM) has become a major global health problem, and its incidence continues to rise, while affecting an increasing number of men in their reproductive years. Type 2 Diabetes Mellitus (T2DM), accounting for about 85-95% of DM, is closely related to the development of sperm. However, the exact association between T2DM and abnormal spermatozoa remains unclear. Herein, we designed a Two-sample Mendelian randomization (MR) study to explore the causal association between T2DM and abnormal spermatozoa risk in European population data which come from the GWAS summary datasets. We selected 9 single nucleotide polymorphisms (SNPs) of T2DM (exposure data) as instrumental variables (IVs), and then retrieved the suitable abnormal spermatozoa genome-wide association study (GWAS) data of European from Ieu Open GWAS Project database which includes 915 cases and 209,006 control as the outcome data. Our results indicate that strict T2DM might not result in a higher risk of abnormal spermatozoa genetically in Europeans (OR: 1.017, 95% confidence interval (CI): 0.771-1.342, =0.902). Our findings demonstrate that only T2DM may not explain the relatively higher risk of abnormal spermatozoa in men with it in Europeans. In subsequent studies, more comprehensive and larger samples need to be studied to reveal the relationship and potential mechanism between T2DM and abnormal spermatozoa.
异常精子不仅会降低受精率，还会延长自然受孕时间，甚至增加自然流产的风险。糖尿病（DM）已成为一个主要的全球健康问题，其发病率持续上升，同时影响到越来越多处于生育年龄的男性。2 型糖尿病（T2DM）占 DM 的 85-95%左右，与精子的发育密切相关。然而，T2DM 与异常精子之间的确切关联尚不清楚。在此，我们设计了一项两样本孟德尔随机化（MR）研究，以探讨欧洲人群 GWAS 汇总数据集的 T2DM 与异常精子风险之间的因果关系。我们选择了 9 个 T2DM 的单核苷酸多态性（SNP）（暴露数据）作为工具变量（IVs），然后从 Ieu Open GWAS 项目数据库中检索到适合的欧洲人异常精子全基因组关联研究（GWAS）数据，其中包括 915 例病例和 209,006 例对照作为结局数据。我们的结果表明，严格的 T2DM 可能不会导致欧洲人异常精子的遗传风险增加（OR：1.017，95%置信区间（CI）：0.771-1.342，=0.902）。我们的研究结果表明，只有 T2DM 可能无法解释欧洲人 T2DM 患者异常精子风险相对较高的原因。在后续研究中，需要进行更全面和更大样本的研究，以揭示 T2DM 和异常精子之间的关系和潜在机制。
