Qiu Zhengqi, Jia Xueyuan, Li Yufei, Fu Yancheng, Xiao Ying
Faculty of Medicine, Macau University of Science and Technology, Est. Seak Pai Van Praia Park, Rés-Do-Chão R, Coloane, Macao, 999078, China.
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Endocrine. 2024 Jul;85(1):158-167. doi: 10.1007/s12020-024-03723-5. Epub 2024 Feb 12.
This study aimed to investigate the potential causal relationship between screen time and the risk of developing type 2 diabetes mellitus (T2DM) using Mendelian randomization.
Two-sample Mendelian randomization was conducted, utilizing genetic variants associated with different types of screen time as instrumental variables. Single nucleotide polymorphisms (SNPs) were used to assess the primary outcome, which was the risk of developing T2DM.
The analysis revealed a significant positive causal association between television viewing time and the risk of T2DM. Specifically, excessive television viewing time was found to increase the risk of developing T2DM (OR: 2.39, 95% CI: 1.90 to 3.00, P < 0.01). However, no significant causal relationship was observed between computer usage time and the risk of T2DM. Additionally, mobile phone use time showed a positive correlation with the risk of T2DM (OR: 1.31, 95% CI: 1.04 to 1.64, P = 0.02), albeit to a lesser extent than television viewing time.
The findings of this study indicate a significant causal association between certain types of screen time, specifically television viewing and mobile phone use, and an increased risk of T2DM.
本研究旨在利用孟德尔随机化方法探讨屏幕使用时间与2型糖尿病（T2DM）发病风险之间的潜在因果关系。
采用两样本孟德尔随机化方法，将与不同类型屏幕使用时间相关的基因变异作为工具变量。使用单核苷酸多态性（SNP）评估主要结局，即患T2DM的风险。
分析显示，看电视时间与T2DM风险之间存在显著的正因果关联。具体而言，发现过多的看电视时间会增加患T2DM的风险（比值比：2.39，95%置信区间：1.90至3.00，P < 0.01）。然而，未观察到使用电脑时间与T2DM风险之间存在显著因果关系。此外，使用手机时间与T2DM风险呈正相关（比值比：1.31，95%置信区间：1.04至1.64，P = 0.02），尽管程度低于看电视时间。
本研究结果表明，某些类型的屏幕使用时间，特别是看电视和使用手机，与T2DM风险增加之间存在显著的因果关联。
