尼日利亚河流州哈科特港孕妇中使用磺胺多辛-乙胺嘧啶预防疟疾的效果和依从性。

Effectiveness and compliance to the use of sulphadoxine-pyrimethamine as a prophylaxis for malaria among pregnant women in Port Harcourt, Rivers State, Nigeria.

机构信息

Department of Animal and Environmental Biology, Faculty of Science, University of Port Harcourt. Rivers State, Nigeria.

出版信息

Afr Health Sci. 2022 Jun;22(2):187-193. doi: 10.4314/ahs.v22i2.22.

DOI:10.4314/ahs.v22i2.22

PMID:36407362

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9652641/

Abstract

BACKGROUND

Malaria during pregnancy escalates the damaging consequence to the mother and neonate. The usage of intermittent preventive treatment of malaria (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for averting the deleterious consequences of malaria in pregnancy. This study evaluated the effectiveness of, and compliance with the use of SP for malaria among pregnant women in Port Harcourt Rivers State, Nigeria.

METHOD

A total of 300 samples of maternal peripheral blood (MPB), 84 neonatal cord blood (NCB) and 84 placental blood (PLB) were collected from consenting mothers. Malaria parasitaemia were analysed using standard parasitological methods, and bio-data of consenting mothers were collected through questionnaires and from ANC records.

RESULTS

Out of the samples examined for MPB, 59(19.7%) tested positive to malaria. Those with only primary education (57.1%) and women of age ≤ 20yrs (25%) had higher prevalence. Women who took SP had significantly lower prevalence (17.6%) than those that took other drugs (36.4%) (p < 0.05). Malaria prevalence was highest among women who had 3 months interval between each dose (39.1%), followed by those of 2months (23.7%) and those of 1 month (7.0%) (p < 0.05). The primigravidaes (22.8%) had an insignificantly higher prevalence than secundigravidae (19.4%) and multigravidae (15.9%). Also, 30.5% of women who registered in their third trimester of pregnancy had a significantly higher malaria parasitaemia than those who registered during their first 8.10%, or second trimesters, 19.4%. Of the 84 MPB-NCB-PLB pairedamples examined, 16.7%, 8.3% and 25% respectively were infected with malaria parasitaemia. On frequency of compliance, mothers who took SP once (37.5%) had a significantly higher MPB parasitaemia than those who took it twice (7.84%) and those of thrice (6.25%). Neonatal cord blood parasitaemia prevalence revealed that those that took SP once, that is, 25%, had a higher prevalence than others like those of twice (5.88%) and thrice (0%) respectively.

CONCLUSION

The use and compliance of SP reduced the prevalence of malaria among pregnant women and their new-borns.

摘要

背景

孕期疟疾会加剧母婴的损害后果。推荐使用磺胺多辛-乙胺嘧啶（SP）间歇性预防治疗疟疾（IPTp），以避免孕期疟疾的有害后果。本研究评估了尼日利亚哈科特港河流州孕妇使用 SP 治疗疟疾的效果和依从性。

方法

从同意的母亲中收集了 300 份产妇外周血（MPB）、84 份新生儿脐带血（NCB）和 84 份胎盘血（PLB）样本。使用标准寄生虫学方法分析疟疾寄生虫血症，通过问卷和 ANC 记录收集同意母亲的生物数据。

结果

在检查的 MPB 样本中，有 59 例（19.7%）检测出疟疾阳性。只有小学教育程度（57.1%）和年龄≤20 岁的妇女（25%）的患病率较高。服用 SP 的妇女的患病率明显低于服用其他药物的妇女（36.4%）（p<0.05）。每剂间隔 3 个月的妇女（39.1%）、每剂间隔 2 个月的妇女（23.7%）和每剂间隔 1 个月的妇女（7.0%）的疟疾患病率最高（p<0.05）。初产妇（22.8%）的患病率略高于经产妇（19.4%）和多产妇（15.9%）。此外，在妊娠第 3 期登记的妇女中，有 30.5%的疟疾寄生虫血症明显高于在第 1 期（8.1%）或第 2 期登记的妇女，为 19.4%。在 84 对 MPB-NCB-PLB 配对样本中，分别有 16.7%、8.3%和 25%的样本感染了疟疾寄生虫血症。在依从性频率方面，服用 SP 一次（37.5%）的母亲的 MPB 寄生虫血症明显高于服用两次（7.84%）和三次（6.25%）的母亲。新生儿脐带血寄生虫血症患病率显示，服用 SP 一次（25%）的婴儿患病率高于服用两次（5.88%）和三次（0%）的婴儿。