尼日利亚河流州哈科特港的磺胺多辛-乙胺嘧啶对母婴和胎盘疟疾的影响。

Effects of sulphadoxine-pyrimethamine on maternal, neonatal and placental malaria in Port Harcourt, Rivers State, Nigeria.

机构信息

Department of Animal and Environmental Biology, Faculty of Science, University of Port Harcourt, Rivers State, Nigeria.

出版信息

J Vector Borne Dis. 2023 Jul-Sep;60(3):285-291. doi: 10.4103/0972-9062.374243.

Abstract

BACKGROUND & OBJECTIVES: The utilization of Intermittent Preventive Treatment (sulphadoxine-pyrimethamine) in pregnancy (IPTp-SP) for combating malaria has indicated control over adverse birth outcomes and has been recommended for use by pregnant women. The aim of this study was to determine the effectiveness of IPTp-SP on maternal, neonatal and placental malaria in Port Harcourt, Nigeria.

METHODS

316 samples of maternal peripheral blood (MPB), placental blood (PLB), neonatal cord blood (NCB) and placental tissue (PT) were collected each from consenting mothers. Blood samples were processed and stained by the Giemsa method. Placental tissues were processed and stained in haematoxylin. Examination of samples for malaria parasitaemia was carried out using standard parasitological methods. Demography of participants was collected through questionnaires and from ante natal care (ANC) records.

RESULTS

Overall prevalence of 74 (23.42%) was recorded. Age-related prevalence indicated that ≤ 20 years, 9 (56.25%) had the highest prevalence followed by 21-30 years (23.48%), and ≥41 years (16.67%) (p <0.05). Malaria in MPB showed that SP-users had 26 (13.20%) while non-users had 48 (40.33%) (p <0.05). In NCB, SP-users recorded 20 (10.15%) while non-users had 13 (10.92) (p>0.05). The prevalence in PLB and PT revealed that SP-users had a lower prevalence in PLB, 31 (15.73%) and PT, 12 (6.09%) while non-users recorded a higher prevalence 48 (40.33%) in PLB and 21 (17.65%) in PT (P<0.05).

INTERPRETATION & CONCLUSION: The utilization of IPTp-SP is seen to significantly reduce the occurrence of malaria in pregnancy, placental tissue and in neonates thereby helping in improving birth outcomes.

摘要

背景与目的

间歇性预防治疗（磺胺多辛-乙胺嘧啶）在妊娠中的应用（IPTp-SP）用于对抗疟疾，已显示出对不良母婴结局的控制作用，并被推荐给孕妇使用。本研究旨在确定 IPTP-SP 在尼日利亚哈科特港的母婴、新生儿和胎盘疟疾中的有效性。

方法

从同意的母亲中采集了 316 份母亲外周血（MPB）、胎盘血（PLB）、新生儿脐带血（NCB）和胎盘组织（PT）样本。血液样本用吉姆萨方法处理和染色。胎盘组织用苏木精处理和染色。用标准寄生虫学方法检查样本中的疟原虫寄生虫血症。通过问卷和产前保健（ANC）记录收集参与者的人口统计学资料。

结果

总患病率为 74 例（23.42%）。与年龄相关的患病率表明，≤ 20 岁的人群中，最高患病率为 9 例（56.25%），其次是 21-30 岁（23.48%）和≥41 岁（16.67%）（p<0.05）。MPB 中的疟疾表明，SP 使用者有 26 例（13.20%），而非使用者有 48 例（40.33%）（p<0.05）。NCB 中，SP 使用者记录到 20 例（10.15%），而非使用者记录到 13 例（10.92%）（p>0.05）。PLB 和 PT 的患病率显示，SP 使用者在 PLB 中的患病率较低，为 31 例（15.73%），在 PT 中的患病率较低，为 12 例（6.09%），而非使用者在 PLB 中的患病率较高，为 48 例（40.33%），在 PT 中的患病率较高，为 21 例（17.65%）（P<0.05）。