• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

O标记水在人内耳中的分布：对淋巴动力学和前庭功能的见解。

O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function.

作者信息

Yoshida Tadao, Naganawa Shinji, Kobayashi Masumi, Sugimoto Satofumi, Katayama Naomi, Nakashima Tsutomu, Kato Yutaka, Ichikawa Kazushige, Yamaguchi Hiroshi, Nishida Kazuki, Sone Michihiko

机构信息

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

出版信息

Front Neurol. 2022 Nov 3;13:1016577. doi: 10.3389/fneur.2022.1016577. eCollection 2022.

DOI:10.3389/fneur.2022.1016577
PMID:36408495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9668890/
Abstract

We evaluated the inner ear distribution of O-labeled saline administered to the human tympanic cavity. Magnetic resonance imaging was performed after intratympanic administration in five healthy volunteers and one patient with cochlear endolymphatic hydrops. In all volunteers, O-labeled water permeated the cochlear basal turn and vestibule at 30 min and disappeared gradually within 2-4 h. All participants experienced positional vertigo lasting a few hours to a few days. Visualization of O-labeled water distribution in the endolymphatic space of the posterior ampulla showed indistinct separation of endolymph and perilymph in the cochlea and most of the vestibule in all participants. Intralabyrinthine distribution of O-labeled water differed from that in previous reports of intratympanically administered gadolinium-based contrast agent. O-labeled water in the endolymphatic space may cause heavier endolymph and positional vertigo. These results of this study may add new insights for investigating the distribution and the effects of molecules in the inner ear after the intratympanic administration in living humans.

摘要

我们评估了注入人鼓室的氧标记盐水在内耳的分布情况。对5名健康志愿者和1名患有耳蜗内淋巴积水的患者进行鼓室内给药后，进行了磁共振成像。在所有志愿者中，氧标记水在30分钟时渗透到耳蜗底转和前庭，并在2 - 4小时内逐渐消失。所有参与者均经历了持续数小时至数天的位置性眩晕。对后半规管内淋巴间隙中氧标记水分布的可视化显示，所有参与者的耳蜗和大部分前庭内淋巴和外淋巴的分离不明显。氧标记水在迷路内的分布与先前关于鼓室内注射钆基造影剂的报道不同。内淋巴间隙中的氧标记水可能会导致内淋巴加重和位置性眩晕。本研究的这些结果可能为研究活体人类鼓室内给药后内耳中分子的分布和作用提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/19d647942a7a/fneur-13-1016577-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/5592e1b863f9/fneur-13-1016577-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/628f2cacad47/fneur-13-1016577-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/189f493b9943/fneur-13-1016577-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/660f95e17c10/fneur-13-1016577-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/eaed713185ba/fneur-13-1016577-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/6efa086721b6/fneur-13-1016577-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/87051e49b902/fneur-13-1016577-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/9cdaeac2ee2a/fneur-13-1016577-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/65614c9ba0cd/fneur-13-1016577-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/19d647942a7a/fneur-13-1016577-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/5592e1b863f9/fneur-13-1016577-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/628f2cacad47/fneur-13-1016577-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/189f493b9943/fneur-13-1016577-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/660f95e17c10/fneur-13-1016577-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/eaed713185ba/fneur-13-1016577-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/6efa086721b6/fneur-13-1016577-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/87051e49b902/fneur-13-1016577-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/9cdaeac2ee2a/fneur-13-1016577-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/65614c9ba0cd/fneur-13-1016577-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f48b/9668890/19d647942a7a/fneur-13-1016577-g0010.jpg

相似文献

1
O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function.O标记水在人内耳中的分布：对淋巴动力学和前庭功能的见解。
Front Neurol. 2022 Nov 3;13:1016577. doi: 10.3389/fneur.2022.1016577. eCollection 2022.
2
[Visualization of endolymphatic hydrops in 3D-FLAIR MRI after intratympanic Gd-DTPA administration in Meniere's disease patients].[梅尼埃病患者鼓室内注射钆喷酸葡胺后3D-FLAIR MRI对内淋巴积水的可视化]
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Aug;48(8):628-33.
3
Visualization of endolymphatic hydrops in patients with Meniere's disease.梅尼埃病患者内淋巴积水的可视化。
Laryngoscope. 2007 Mar;117(3):415-20. doi: 10.1097/MLG.0b013e31802c300c.
4
[Optimization of delivering minimum Gd-DTPA at the posterior upper point on tympanic medial wall and hT2W-3D-FLAIR sequence for detecting endolymphatic hydrops].[鼓膜内侧壁后上方点最小剂量钆喷酸葡胺给药及hT2W-3D-FLAIR序列用于检测内淋巴积水的优化]
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Dec 7;53(12):931-938. doi: 10.3760/cma.j.issn.1673-0860.2018.12.011.
5
Signal and morphological changes in the endolymph of patients with vestibular schwannoma on non-contrast 3D FLAIR at 3 Tesla.3T 磁共振非增强三维液体衰减反转恢复序列（FLAIR）成像前庭神经鞘瘤患者内淋巴液的信号和形态变化。
BMC Med Imaging. 2021 Sep 25;21(1):135. doi: 10.1186/s12880-021-00670-9.
6
Comparison of noninvasive evaluation of endolymphatic hydrops in Meniere's disease and endolymphatic space in healthy volunteers using magnetic resonance imaging.使用磁共振成像对梅尼埃病内淋巴积水和健康志愿者内淋巴间隙进行无创评估的比较。
Acta Otolaryngol. 2012 Mar;132(3):234-40. doi: 10.3109/00016489.2011.637232. Epub 2011 Dec 27.
7
[ dynamic changes of inner ear guinea pigs with 9.4 T esla MRI].[9.4特斯拉磁共振成像对内耳豚鼠的动态变化研究]
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Apr 7;55(4):378-383. doi: 10.3760/cma.j.cn115330-20190727-00467.
8
Clinical high-resolution imaging and grading of endolymphatic hydrops in Hydropic Ear Disease at 1.5 T using the two-slice grading for vestibular endolymphatic hydrops in less than 10 min.利用1.5T磁共振成像，采用两片式分级法，在不到10分钟的时间内对耳积水病中的内淋巴积水进行临床高分辨率成像和分级。
Eur Arch Otorhinolaryngol. 2022 Feb;279(2):751-757. doi: 10.1007/s00405-021-06731-7. Epub 2021 Mar 9.
9
Semi-quantitative evaluation of endolymphatic hydrops by bilateral intratympanic gadolinium-based contrast agent (GBCA) administration with MRI for Meniere's disease.通过双侧鼓室内注射钆基造影剂（GBCA）并结合MRI对梅尼埃病内淋巴积水进行半定量评估。
Acta Otolaryngol. 2010;130(1):10-6. doi: 10.3109/00016480902858881.
10
Clinical significance of endolymphatic imaging after intratympanic gadolinium injection.鼓室内注射钆后内淋巴成像的临床意义
Acta Otolaryngol Suppl. 2009 Feb(560):9-14. doi: 10.1080/00016480902729801.

引用本文的文献

1
Blood Labyrinth Barrier Waste Clearance as Assessed by GBCAs on MRI: A Scoping Review.基于钆对比剂的MRI评估血脑屏障废物清除：一项范围综述
Laryngoscope Investig Otolaryngol. 2025 Sep 9;10(5):e70240. doi: 10.1002/lio2.70240. eCollection 2025 Oct.
2
New non-contrast MRI of endolymphatic hydrops in Ménière's disease considering inversion time.考虑反转时间的梅尼埃病内淋巴积水的新型非对比磁共振成像
Laryngoscope Investig Otolaryngol. 2024 Aug 10;9(4):e1314. doi: 10.1002/lio2.1314. eCollection 2024 Aug.
3
Visualization of distribution in the vitreous cavity via eye drops using ultra-heavily T2-weighted sequences in MRI: a preliminary study with enucleated pig eyes.

本文引用的文献

1
The glymphatic system: implications for drugs for central nervous system diseases.糖酵解系统：对中枢神经系统疾病药物的影响。
Nat Rev Drug Discov. 2022 Oct;21(10):763-779. doi: 10.1038/s41573-022-00500-9. Epub 2022 Aug 10.
2
Quantitative magnetic resonance imaging for evaluating of the cerebrospinal fluid kinetics with 17O-labeled water tracer: A preliminary report.应用 17O 标记水示踪剂的定量磁共振成像评估脑脊液动力学：初步报告。
Magn Reson Imaging. 2022 Apr;87:77-85. doi: 10.1016/j.mri.2021.12.005. Epub 2021 Dec 28.
3
Evaluation of the blood-perilymph barrier in ears with endolymphatic hydrops.
通过 MRI 中的超高 T2 加权序列对眼内液中分布的可视化：用离体猪眼进行的初步研究。
Radiol Phys Technol. 2024 Sep;17(3):715-724. doi: 10.1007/s12194-024-00826-6. Epub 2024 Jul 18.
4
Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging.使用磁共振成像直接可视化示踪剂渗透到人类患者内淋巴中的情况。
Magn Reson Med Sci. 2025 Apr 1;24(2):253-261. doi: 10.2463/mrms.mp.2024-0011. Epub 2024 Apr 3.
5
Magnetic Resonance Water Tracer Imaging Using 17 O-Labeled Water.使用¹⁷O标记水的磁共振水示踪成像
Invest Radiol. 2024 Jan 1;59(1):92-103. doi: 10.1097/RLI.0000000000001021. Epub 2023 Sep 15.
6
The Glymphatic System in Humans: Investigations With Magnetic Resonance Imaging.人体中的类淋巴系统：磁共振成像研究
Invest Radiol. 2024 Jan 1;59(1):1-12. doi: 10.1097/RLI.0000000000000969. Epub 2023 Mar 13.
评估内淋巴积水耳中的血迷路屏障。
Acta Otolaryngol. 2021 Aug;141(8):736-741. doi: 10.1080/00016489.2021.1957500. Epub 2021 Aug 4.
4
Altered glymphatic system in idiopathic normal pressure hydrocephalus.特发性正常压力脑积水患者的糖液系统改变。
Parkinsonism Relat Disord. 2021 Jan;82:56-60. doi: 10.1016/j.parkreldis.2020.11.009. Epub 2020 Nov 20.
5
Do normal-tension and high-tension glaucoma result from brain and ocular glymphatic system disturbances, respectively?正常眼压性青光眼和高眼压性青光眼分别是由脑和眼的类淋巴系统紊乱引起的吗？
Eye (Lond). 2021 Oct;35(10):2905-2906. doi: 10.1038/s41433-020-01219-w. Epub 2020 Oct 12.
6
Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics.中枢神经系统（CNS）细胞外液病的影像学：细胞外液动力学障碍性疾病。
Jpn J Radiol. 2021 Jan;39(1):1-14. doi: 10.1007/s11604-020-01017-0. Epub 2020 Jul 11.
7
Significance of high signal intensity in the endolymphatic duct on magnetic resonance imaging in ears with otological disorders.耳部疾病患者磁共振成像中内淋巴管高信号的意义。
Acta Otolaryngol. 2020 Oct;140(10):818-822. doi: 10.1080/00016489.2020.1781927. Epub 2020 Jul 10.
8
Neurodegeneration in Alzheimer's disease and glaucoma: overlaps and missing links.阿尔茨海默病和青光眼的神经退行性变：重叠和缺失的环节。
Eye (Lond). 2020 Sep;34(9):1546-1553. doi: 10.1038/s41433-020-0836-x. Epub 2020 Mar 9.
9
Glymphatic imaging using MRI.使用磁共振成像进行淋巴系统成像。
J Magn Reson Imaging. 2020 Jan;51(1):11-24. doi: 10.1002/jmri.26892. Epub 2019 Aug 18.
10
Imaging of Temporal Bone.颞骨影像学
Adv Otorhinolaryngol. 2019;82:12-31. doi: 10.1159/000490268. Epub 2019 Jan 15.