Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt.
Department Chemie, Ludwig-Maximilians-Universität München, München, Germany.
Nat Prod Res. 2024 Apr;38(8):1414-1423. doi: 10.1080/14786419.2022.2148246. Epub 2022 Nov 21.
A binuclear La(III) complex {[La(HA)(HO)(CHOH)Cl]Cl ()} with 2-aminobenzoic acid (HA) was prepared from the ligand and heptahydrated lanthanum chloride. The complex was characterised by X-ray crystallography that revealed anti-prismatic geometry around both of the lanthanum. In the complex, the four 2-aminobenzoic acid ligands are zwitter ionic and the two lanthanum(III) ions net charge is only counterbalanced by chloride ions. The complex cytotoxicity was determined against human breast (MDA-MB-231), prostate (PC-3) and bladder (T-24) cancer cells. This complex afforded cytotoxicity towards the T-24 bladder cancer cells with an IC value of 383.5 µg/mL (319 µM). In contrary, activities by the lanthanum complex with IC values of 1124 µg/mL (934 µM) and 739 µg/mL (614 µM) were, respectively, shown against the MDA-MB-231 and PC-3 cancer cells. This means the complex is more cytotoxic against the T-24 cells, despite that its activity is less compared with activities shown by classical drugs.
双核镧（III）配合物{[La（HA）（HO）（CHOH）Cl]Cl()}是由配体和七水合氯化镧制备的。配合物通过 X 射线晶体学进行了表征，结果表明镧的两个配合物均具有反棱柱几何形状。在该配合物中，四个 2-氨基苯甲酸配体为两性离子，两个镧（III）离子的净电荷仅由氯离子平衡。测定了该配合物对人乳腺癌（MDA-MB-231）、前列腺癌（PC-3）和膀胱癌（T-24）癌细胞的细胞毒性。该配合物对 T-24 膀胱癌细胞具有细胞毒性，IC 值为 383.5μg/mL（319μM）。相反，镧配合物对 MDA-MB-231 和 PC-3 癌细胞的 IC 值分别为 1124μg/mL（934μM）和 739μg/mL（614μM），显示出活性。这意味着该配合物对 T-24 细胞的细胞毒性更强，尽管其活性与经典药物相比有所降低。
