Department of Chemistry, Faculty of Science, Assiut University, Assiut, 71516, Egypt.
Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Haus, D 81377, München, Germany.
Biol Trace Elem Res. 2023 Oct;201(10):4688-4696. doi: 10.1007/s12011-022-03545-4. Epub 2023 Jan 5.
This paper presents the synthesis and isolation of a new binuclear complex of yttrium with anthranilic acid (HA). The complex [Y(HA)(HO)] Cl.2CHOH (C1) was obtained as single crystals that its X-ray analysis revealed its triclinic P-1 space group in addition to anti-prismatic geometry around each of the yttrium ions. In the complex, the anthranilic acid ligands are bidentate, zwitter ionic and neutral, and the yttrium ions' charge is only compensated by six chloride ions. The cytotoxicity of this complex against human breast cancer MDA-MB-231 cells, prostate cancer PC-3 cells, and bladder cancer T-24 cells was evaluated. This yttrium complex displayed more cytotoxic activity against the bladder cancer cells with an IC value of 307.7 μg/ml (223 μM). On the other hand, the activities of complex C1 against the MDA-MB-231 and PC-3 cells were less significant respectively with IC values of 1097 μg/ml (796 μM) and 921 μg/ml (669 μM).
本文提出了一种新型双核钇配合物与邻氨基苯甲酸（HA）的合成与分离。该配合物[Y(HA)(HO)]Cl.2CHOH（C1）以单晶形式获得，其 X 射线分析表明其具有三斜 P-1 空间群，以及每个钇离子周围的反棱柱几何形状。在该配合物中，邻氨基苯甲酸配体是双齿的、两性离子的和中性的，而钇离子的电荷仅由六个氯离子补偿。该配合物对人乳腺癌 MDA-MB-231 细胞、前列腺癌 PC-3 细胞和膀胱癌 T-24 细胞的细胞毒性进行了评估。该钇配合物对膀胱癌细胞具有更强的细胞毒性活性，IC 值为 307.7μg/ml（223μM）。另一方面，配合物 C1 对 MDA-MB-231 和 PC-3 细胞的活性则不那么显著，IC 值分别为 1097μg/ml（796μM）和 921μg/ml（669μM）。
