Future Industries Institute and STEM Academic Unit, University of South Australia, Adelaide, South Australia, Australia.
Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain.
Am J Physiol Cell Physiol. 2023 Jan 1;324(1):C29-C38. doi: 10.1152/ajpcell.00080.2022. Epub 2022 Nov 21.
Healing of cutaneous wounds is a fundamental process required to re-establish tissue integrity, repair skin barrier function, and restore skin homeostasis. Chronic wound infection, exacerbated by the growing development of resistance to conventional therapies, hinders the skin repair process and is a serious clinical problem affecting millions of people worldwide. In the past decade, the use of antimicrobial peptides (AMPs) has attracted increasing attention as a potential novel strategy for the treatment of chronic wound infections due to their unique multifaceted mechanisms of action, and AMPs have been demonstrated to function as potent host-defense molecules that can control microbial proliferation, modulate host-immune responses, and act as endogenous mediators of wound healing. To date over 3,200 AMPs have been discovered either from living organisms or through synthetic derivation, some of which have progressed to clinical trials for the treatment of burn and wound injuries. However, progress to routine clinical use has been hindered due to AMPs' susceptibility to wound and environmental factors including changes in pH, proteolysis, hydrolysis, oxidation, and photolysis. This review will discuss the latest research focused on the development and applications of AMPs for wound infections using the latest nanotechnological approaches to improve AMP delivery, and stability to present effective combinatorial treatment for clinical applications.
皮肤创伤的愈合是重建组织完整性、修复皮肤屏障功能和恢复皮肤内稳态的基本过程。慢性伤口感染因传统疗法耐药性的不断发展而加剧，阻碍了皮肤修复过程，是一个严重的全球性临床问题，影响着全球数百万人。在过去十年中，由于其独特的多效作用机制，抗菌肽（AMPs）作为治疗慢性伤口感染的一种潜在新策略，引起了越来越多的关注。AMPs 被证明是有效的宿主防御分子，可以控制微生物的增殖、调节宿主免疫反应，并作为伤口愈合的内源性介质。迄今为止，已经从生物体中或通过合成衍生发现了超过 3200 种 AMPs，其中一些已经进展到临床试验，用于治疗烧伤和创伤。然而，由于 AMPs 易受伤口和环境因素（包括 pH 值变化、蛋白水解、水解、氧化和光解）的影响，其常规临床应用受到阻碍。本综述将讨论最新的研究进展，重点介绍使用最新的纳米技术方法来改善 AMP 传递和稳定性，以提供有效的联合治疗，从而用于临床应用的 AMP 治疗伤口感染的开发和应用。
