Zajicek G
Med Hypotheses. 1986 Sep;21(1):105-15. doi: 10.1016/0306-9877(86)90067-8.
Cancer is regarded here as a metabolic deficiency originating in stem cell destruction. Tissue stem cells are postulated to secrete a vital substance 'A' necessary for proper tissue function. Carcinogens interfere with 'A' production mainly by destroying stem cells which the organism is incapable of fully replenishing so that less 'A' is produced. This irreversible 'A' deficiency may be compensated by a substitute, or substance 'B', produced by a specialized organ, the neoplasm. Since carcinogens continue depleting more and more stem cells, the deficiency worsens. In order to meet the increasing demand, the neoplasm proliferates more and more until reaching a stage of decompensation when the harm inflicted by it outweighs its benefit. Stem cell depletion is regarded here as the final common pathway for carcinogen action. The theory predicts that following a supply of 'A' producing stem cells or inactivated 'B' producing neoplastic stem cells, the tumor will regress.
在此，癌症被视为一种源于干细胞破坏的代谢缺陷。组织干细胞被假定可分泌一种对组织正常功能至关重要的物质“A”。致癌物主要通过破坏机体无法完全补充的干细胞来干扰“A”的产生，从而使“A”的产量减少。这种不可逆的“A”缺乏可能由肿瘤这一特殊器官产生的替代物或物质“B”来补偿。由于致癌物持续消耗越来越多的干细胞，缺乏情况会恶化。为了满足不断增加的需求，肿瘤会不断增殖，直至达到失代偿阶段，此时肿瘤造成的危害超过其益处。在此，干细胞耗竭被视为致癌物作用的最终共同途径。该理论预测，在供应产生“A”的干细胞或失活的产生“B”的肿瘤干细胞后，肿瘤将会消退。
