Foscolo Valentina, de Gennaro Luigi, Murri Alessandra, Speranzon Luca, Signorelli Francesco, Quaranta Nicola, Messina Raffaella
Otolaryngology Unit, Department of Translational Biomedicine and Neurosciences (DiBraiN), University "Aldo Moro" of Bari, 70124 Bari, Italy.
Division of Neurosurgery, Department of Translational Biomedicine and Neurosciences (DiBraiN), University "Aldo Moro" of Bari, 70124 Bari, Italy.
Audiol Res. 2022 Nov 17;12(6):635-643. doi: 10.3390/audiolres12060061.
Vestibular Schwannomas are benign tumors arising from the VIII CN. Surgical treatment is indicated in case of tumors larger than 2.5 cm in the cerebellopontine angle or in the case of cranial nerve dysfunction. The aim of the present study was to evaluate the QoL by means of the PANQOL questionnaire in a group of surgically treated patients mainly affected by large and giant VS Methods: All patients underwent preoperative and postoperative otoneurological evaluation and gadolinium enhanced MRI and they completed, independently, the PANQOL questionnaire at last follow up.
70% of patients presented with large Koos III or IV VS Each domain of PANQOL showed a strong correlation with the total PANQOL score. In relation to the postoperative facial nerve function, patients with poorer function showed significantly lower score in the facial dysfunction and pain, patients with postoperative balance problems showed a significantly lower PANQOL score for domains of balance and pain.
This study showed that postoperative QoL of patients was acceptable even if there were some domains that were more affected, such as hearing and balance domains; therefore, the lowest scores suggest the need for vestibular rehabilitation programs and strategies that improve postoperative hearing.
前庭神经鞘瘤是起源于第八对脑神经的良性肿瘤。对于桥小脑角区肿瘤大于2.5 cm或出现脑神经功能障碍的情况，需进行手术治疗。本研究旨在通过PANQOL问卷评估一组主要受大型和巨大型前庭神经鞘瘤影响的手术治疗患者的生活质量。方法：所有患者均接受术前和术后耳神经学评估及钆增强磁共振成像，并在最后一次随访时独立完成PANQOL问卷。
70%的患者表现为大型库斯III级或IV级前庭神经鞘瘤。PANQOL的每个领域与PANQOL总分均显示出强烈的相关性。关于术后面神经功能，功能较差的患者在面部功能障碍和疼痛方面的得分显著较低，术后有平衡问题的患者在平衡和疼痛领域的PANQOL得分显著较低。
本研究表明，即使存在一些受影响较大的领域，如听力和平衡领域，患者的术后生活质量仍可接受；因此，最低得分表明需要前庭康复计划和策略来改善术后听力。
