Pondugala Vidya Vardhini, Mishra Krishnaveni
Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India.
Noncoding RNA. 2022 Nov 15;8(6):77. doi: 10.3390/ncrna8060077.
Cells change their physiological state in response to environmental cues. In the absence of nutrients, unicellular fungi such as budding yeast exit mitotic proliferation and enter the meiotic cycle, leading to the production of haploid cells that are encased within spore walls. These cell state transitions are orchestrated in a developmentally coordinated manner. Execution of the meiotic cell cycle program in budding yeast, , is regulated by the key transcription factor, Ime1. Recent developments have uncovered the role of non-coding RNA in the regulation of Ime1 and meiosis. In this review, we summarize the role of ncRNA-mediated and RNA homeostasis-based processes in the regulation of meiosis in .
细胞会根据环境线索改变其生理状态。在缺乏营养的情况下，诸如出芽酵母之类的单细胞真菌会退出有丝分裂增殖并进入减数分裂周期，从而产生包裹在孢子壁内的单倍体细胞。这些细胞状态转变是以发育协调的方式精心安排的。出芽酵母中减数分裂细胞周期程序的执行受关键转录因子Ime1调控。最近的研究进展揭示了非编码RNA在Ime1和减数分裂调控中的作用。在本综述中，我们总结了ncRNA介导的和基于RNA稳态的过程在酿酒酵母减数分裂调控中的作用。
