Zhang Peijing, Wu Wenyi, Chen Qi, Chen Ming
Department of Bioinformatics, State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310058, China.
J Integr Bioinform. 2019 Jul 13;16(3):20190027. doi: 10.1515/jib-2019-0027.
Eukaryotic genomes are pervasively transcribed. Besides protein-coding RNAs, there are different types of non-coding RNAs that modulate complex molecular and cellular processes. RNA sequencing technologies and bioinformatics methods greatly promoted the study of ncRNAs, which revealed ncRNAs' essential roles in diverse aspects of biological functions. As important key players in gene regulatory networks, ncRNAs work with other biomolecules, including coding and non-coding RNAs, DNAs and proteins. In this review, we discuss the distinct types of ncRNAs, including housekeeping ncRNAs and regulatory ncRNAs, their versatile functions and interactions, transcription, translation, and modification. Moreover, we summarize the integrated networks of ncRNA interactions, providing a comprehensive landscape of ncRNAs regulatory roles.
真核生物基因组被广泛转录。除了蛋白质编码RNA外，还有不同类型的非编码RNA，它们调节复杂的分子和细胞过程。RNA测序技术和生物信息学方法极大地促进了对非编码RNA的研究，揭示了非编码RNA在生物功能的各个方面的重要作用。作为基因调控网络中的重要关键参与者，非编码RNA与其他生物分子协同工作，包括编码和非编码RNA、DNA和蛋白质。在这篇综述中，我们讨论了不同类型的非编码RNA，包括管家非编码RNA和调控非编码RNA，它们的多种功能和相互作用、转录、翻译和修饰。此外，我们总结了非编码RNA相互作用的整合网络，提供了非编码RNA调控作用的全面图景。
