Timofeeva Sofia Vladimorovna, Sherchkova Tatiana Alexandrovna, Shkurat Tatiana Pavlovna
The Department of Genetics, Southern Federal University, 34006 Rostov-on-Don, Russia.
Noncoding RNA. 2022 Nov 18;8(6):78. doi: 10.3390/ncrna8060078.
We conducted this meta-analysis to estimate associations between CDKN2B antisense (CDKN2B-AS) rs2383207 polymorphism and susceptibility to atherosclerosis. A systematic literature research of Google Scholar and PubMed was performed to identify eligible studies. Overall, eight studies were included for meta-analyses. The association was assessed by statistical odds' ratio (OR) with 95% confidence interval (CI). RevMan software (Cochrane Collaboration, 5.3. Copenhagen) was used for the meta-analysis. Pooled overall analyses showed that rs2383207 polymorphism was associated with the risk of atherosclerosis in the whole population. Additional analyses by ethnicity revealed that rs2383207 polymorphism was associated with susceptibility to atherosclerosis in Asians and Caucasians. Our results suggest that rs2383207, might serve as genetic biomarkers of atherosclerosis. Further, studies will be required to confirm the observed association.
我们进行了这项荟萃分析，以评估细胞周期蛋白依赖性激酶2B反义基因（CDKN2B-AS）rs2383207多态性与动脉粥样硬化易感性之间的关联。通过对谷歌学术和PubMed进行系统的文献检索，以确定符合条件的研究。总体而言，纳入了八项研究进行荟萃分析。通过统计优势比（OR）及95%置信区间（CI）评估这种关联。使用RevMan软件（Cochrane协作网，5.3版，哥本哈根）进行荟萃分析。汇总的总体分析表明，rs2383207多态性与整个人群的动脉粥样硬化风险相关。按种族进行的进一步分析显示，rs2383207多态性与亚洲人和高加索人的动脉粥样硬化易感性相关。我们的结果表明，rs2383207可能作为动脉粥样硬化的遗传生物标志物。此外，需要进一步的研究来证实所观察到的关联。
