Biology Department, Xiamen University, Xiamen, Fujian, China.
PLoS One. 2022 Nov 22;17(11):e0277811. doi: 10.1371/journal.pone.0277811. eCollection 2022.
The occurrence of cancer metastasis may be related to stem cells in normal tissues. We searched for patient IDs with both normal tissue stem cell values and TCGA (The Cancer Genome Atlas) clinical data for pairing and obtained 639 sets of data (stemness index of normal tissue, stemness index of tumor tissue, cancer stage, distant metastasis, tumor size) and invasion, and lymph node involvement). However, clinical data on cancer metastasis are of only four stages (e.g., Stage I, II, III, and IV), which cannot show subtle changes continuously. We need to find an effective data mining method to transform this four-valued clinical description into a numerical curve. We data-mine this data through numericalization, sorting, and noise reduction filtering. The results showed that: as the normal tissue stemness value (NS) increased, the tumor tissue stemness value (TS) increased proportionally (1.26 times NS). When NS >0.5, the rate of change in TS decelerated (0.43 times NS), and tumor metastasis began to occur. Clinical indicators, such as cancer stage, distant metastasis, tumor size and invasion, and lymph node involvement, showed that tumor metastasis became more and more severe with the increase of NS. This study suggests that tumor metastasis is triggered when the NS in the patient's body is more significant than 0.5.
癌症转移的发生可能与正常组织中的干细胞有关。我们搜索了同时具有正常组织干细胞值和 TCGA（癌症基因组图谱）临床数据的患者 ID 以进行配对，并获得了 639 组数据（正常组织的干细胞指数、肿瘤组织的干细胞指数、癌症分期、远处转移、肿瘤大小和侵袭、淋巴结受累）。然而，癌症转移的临床数据只有四个阶段（例如，I 期、II 期、III 期和 IV 期），无法连续显示细微变化。我们需要找到一种有效的数据挖掘方法，将这种四值临床描述转化为数值曲线。我们通过数值化、排序和降噪过滤对这些数据进行了挖掘。结果表明：随着正常组织干细胞值（NS）的增加，肿瘤组织干细胞值（TS）呈比例增加（为 NS 的 1.26 倍）。当 NS>0.5 时，TS 的变化率减缓（为 NS 的 0.43 倍），肿瘤开始转移。临床指标，如癌症分期、远处转移、肿瘤大小和侵袭以及淋巴结受累，表明随着 NS 的增加，肿瘤转移变得越来越严重。本研究表明，当患者体内的 NS 显著大于 0.5 时，肿瘤转移就会被触发。
