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1
Inflammatory vaginitis in women on long-term rituximab treatment for autoimmune disorders.长期接受利妥昔单抗治疗自身免疫性疾病的女性的炎症性阴道炎。
BMC Womens Health. 2021 Aug 5;21(1):285. doi: 10.1186/s12905-021-01423-0.
2
Vulvovaginal pyoderma gangrenosum associated with rituximab use in 2 patients with rheumatoid arthritis.2例类风湿关节炎患者使用利妥昔单抗后发生的外阴阴道坏疽性脓皮病
JAAD Case Rep. 2021 Feb 23;10:75-77. doi: 10.1016/j.jdcr.2021.02.013. eCollection 2021 Apr.
3
Incidence, Clinical Features, and Outcomes of Late-Onset Neutropenia From Rituximab for Autoimmune Disease.利妥昔单抗治疗自身免疫性疾病所致迟发性中性粒细胞减少症的发生率、临床特征及转归。
Arthritis Rheumatol. 2021 Feb;73(2):347-354. doi: 10.1002/art.41501. Epub 2020 Dec 29.
4
Anti-CD20 Monoclonal Antibodies for Relapsing and Progressive Multiple Sclerosis.抗 CD20 单克隆抗体治疗复发缓解型和进展型多发性硬化症。
CNS Drugs. 2020 Mar;34(3):269-280. doi: 10.1007/s40263-020-00704-w.
5
A case of rituximab-induced pyoderma gangrenosum.1例利妥昔单抗诱发的坏疽性脓皮病。
JAAD Case Rep. 2018 Oct 29;4(10):979-981. doi: 10.1016/j.jdcr.2018.09.003. eCollection 2018 Nov.
6
Vulvovaginal pyoderma gangrenosum in association with rituximab.与利妥昔单抗相关的外阴阴道坏疽性脓皮病。
JAAD Case Rep. 2018 Oct 4;4(9):907-909. doi: 10.1016/j.jdcr.2018.09.001. eCollection 2018 Oct.
7
Life-threatening rituximab-induced pyoderma gangrenosum successfully treated with intravenous immunoglobulin.静脉注射免疫球蛋白成功治疗危及生命的利妥昔单抗诱导的坏疽性脓皮病
Scand J Rheumatol. 2017 Sep;46(5):413-414. doi: 10.1080/03009742.2016.1241298. Epub 2016 Nov 29.
8
Rituximab causing deep ulcerative suppurative vaginitis/pyoderma gangrenosum.利妥昔单抗引发深部溃疡性化脓性阴道炎/坏疽性脓皮病。
Curr Infect Dis Rep. 2015 May;17(5):478. doi: 10.1007/s11908-015-0478-5.
9
Etiology and management of pyoderma gangrenosum: a comprehensive review.坏疽性脓皮病的病因和治疗：全面综述。
Am J Clin Dermatol. 2012 Jun 1;13(3):191-211. doi: 10.2165/11595240-000000000-00000.
10
Superficial granulomatous pyoderma of the vulva in a patient receiving maintenance rituximab (MabThera) for lymphoma.外阴浅表肉芽肿性脓性皮肤病患者正在接受利妥昔单抗（美罗华）维持治疗淋巴瘤。
J Low Genit Tract Dis. 2011 Apr;15(2):158-60. doi: 10.1097/LGT.0b013e3181eb30ff.

与多发性硬化症患者长期利妥昔单抗治疗相关的炎症性阴道炎。

Inflammatory vaginitis associated with long-term rituximab treatment in a patient with multiple sclerosis.

机构信息

Department of Neurology, Copenhagen University Hospital Danish Multiple Sclerosis Research Center, Glostrup, Denmark

Department of Neurology, Copenhagen University Hospital Danish Multiple Sclerosis Research Center, Glostrup, Denmark.

出版信息

BMJ Case Rep. 2022 Nov 22;15(11):e250425. doi: 10.1136/bcr-2022-250425.

DOI:10.1136/bcr-2022-250425
PMID:36414352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9685188/
Abstract

We describe inflammatory vaginitis as a potential side effect of long-term rituximab treatment for multiple sclerosis in the absence of any other systemic disease or underlying malignancy.More studies are needed to characterise the incidence of inflammatory vaginitis among women on long-term rituximab therapy.

摘要

我们描述了一种潜在的副作用，即长期使用利妥昔单抗治疗多发性硬化症可能导致的炎症性阴道炎，而没有任何其他系统性疾病或潜在恶性肿瘤的存在。需要更多的研究来描述长期接受利妥昔单抗治疗的女性中炎症性阴道炎的发生率。