Selva-Nayagam Priya, Fischer Gayle, Hamann Ian, Sobel Jack, James Craig
Department of Dermatology, Queen Elizabeth Hospital, Adelaide, Australia,
Curr Infect Dis Rep. 2015 May;17(5):478. doi: 10.1007/s11908-015-0478-5.
Pyoderma gangrenosum (PG) is a rare cause of purulent vulvovaginal ulceration. Six recent cases of vulvovaginal pyoderma gangrenosum associated with rituximab are described. All cases were seen in the setting of rituximab used for the treatment of B cell non Hodgkin's lymphoma (NHL). Age range was 50-74; symptoms were present for 2-24 months and severe pain, heavy discharge and large, deep purulent ulcers extending into the vagina were seen. This article reviews previous reports of vulvovaginal pyoderma gangrenosum, discusses important differential diagnoses in this setting, and provides evidence supporting rituximab as the cause of pyoderma gangrenosum in this cohort.
坏疽性脓皮病（PG）是脓性外阴阴道溃疡的罕见病因。本文描述了最近6例与利妥昔单抗相关的外阴阴道坏疽性脓皮病病例。所有病例均发生在利妥昔单抗用于治疗B细胞非霍奇金淋巴瘤（NHL）的情况下。年龄范围为50至74岁；症状持续2至24个月，可见严重疼痛、大量分泌物以及延伸至阴道的大而深的脓性溃疡。本文回顾了既往外阴阴道坏疽性脓皮病的报告，讨论了该情况下重要的鉴别诊断，并提供了支持利妥昔单抗作为该队列中坏疽性脓皮病病因的证据。
