Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Centre for Health Education and Health Promotion, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Prostate Cancer Prostatic Dis. 2023 Jun;26(2):421-428. doi: 10.1038/s41391-022-00610-w. Epub 2022 Nov 21.
Lower urinary tract symptoms (LUTS) are common complaint in urology practice and affecting the quality of life for patients. This article aims to perform a systematic review and meta-analysis on the global prevalence of LUTS overall, and according to different patient characteristics.
We searched MEDLINE and Embase for population-based epidemiological studies reporting the prevalence of LUTS from inception to 1 Jan 2021. Studies which: (1) have enough information on sample size and prevalence; (2) investigate individuals aged 15 or above; and (3) have clear diagnostic criteria for LUTS. We extracted the following information: year of publication; name of the first author; study period; region of recruitment; race; age range; sex; severity; symptoms; and criteria. We pooled rate estimates with exact binomial and test score-based confidence intervals (CIs) using proportions with a random-effects model.
We included 222 studies from 36 countries involving 1,692,110 samples and 632,933 patients with LUTS. The overall prevalence of any and moderate-to-severe LUTS was 63.2% (95% CI = 58.0-68.1) and 31.3% (95% CI = 28.8-33.8), respectively. The most common symptom was storage symptoms (56.7%; 95% CI = 51.0-62.4), followed by voiding symptoms (36.4%; 95% CI = 27.8-45.4) and post-micturition symptoms (30.7%; 95% CI = 19.2-43.6). A higher prevalence of moderate-to-severe LUTS was observed in male subjects (35.2%; 95% CI = 32.1-38.5) and individuals aged ≥60 (39.0%; 95% CI = 33.4-44.8; I = 99.9%). Its prevalence increased from 27.4% (95% CI = 24.5-30.3) in 1990-1999, to 31.9% (95% CI = 27.3-36.7) in 2000-2009 and 36.2% (95% CI = 30.7-41.9) in 2010-2019.
This study was the first comprehensive meta-analysis examining the global prevalence of LUTS. We identified a high level of LUTS prevalence in the general population, with a higher burden in male subjects, older individuals, and the Asian population. There has been an increasing trend in the prevalence of LUTS since the 1990s.
下尿路症状（LUTS）是泌尿科常见的主诉，会影响患者的生活质量。本文旨在对全球 LUTS 的总体患病率进行系统回顾和荟萃分析，并根据不同的患者特征进行分析。
我们检索了 MEDLINE 和 Embase 中自成立以来至 2021 年 1 月 1 日的基于人群的流行病学研究，以报告 LUTS 的患病率。纳入的研究必须：（1）有足够的样本量和患病率信息；（2）调查年龄在 15 岁及以上的个体；（3）有明确的 LUTS 诊断标准。我们提取了以下信息：出版年份；第一作者的姓名；研究期间；招募地区；种族；年龄范围；性别；严重程度；症状；和标准。我们使用比例随机效应模型和基于检验分数的置信区间（CI）来汇总估计率。
我们纳入了来自 36 个国家的 222 项研究，涉及 1692110 个样本和 632933 名患有 LUTS 的患者。任何程度和中重度 LUTS 的总体患病率分别为 63.2%（95%CI=58.0-68.1）和 31.3%（95%CI=28.8-33.8）。最常见的症状是储尿症状（56.7%；95%CI=51.0-62.4），其次是排尿症状（36.4%；95%CI=27.8-45.4）和排尿后症状（30.7%；95%CI=19.2-43.6）。男性（35.2%；95%CI=32.1-38.5）和≥60 岁的个体（39.0%；95%CI=33.4-44.8；I=99.9%）中中重度 LUTS 的患病率更高。其患病率从 1990-1999 年的 27.4%（95%CI=24.5-30.3）上升到 2000-2009 年的 31.9%（95%CI=27.3-36.7），再到 2010-2019 年的 36.2%（95%CI=30.7-41.9）。
这是第一项全面的荟萃分析，研究了全球 LUTS 的患病率。我们发现普通人群中有较高的 LUTS 患病率，男性、年龄较大的个体和亚洲人群的负担更重。自 20 世纪 90 年代以来，LUTS 的患病率呈上升趋势。
