Centre for Relevance & Excellence in Novel drug delivery systems, Shri G. H. Patel Building, Donor's Plaza, Pharmacy Department, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Fatehgunj, Vadodara-390002, Gujarat, India.
Ther Deliv. 2022 Jul;13(7):371-381. doi: 10.4155/tde-2022-0018. Epub 2022 Nov 23.
One of the principal impediments for the treatment of neurological conditions is the lack of ability of most of the medicinal agents to evade the blood-brain barrier. Among all the novel approaches to bypass the blood-brain barrier, nose to brain transport is the most patient compliant, non-invasive and effective approach. It directly transports drugs to the CNS via the trigeminal and olfactory nerves present in the nasal cavity. This review article focuses on anatomy and physiology of nasal cavity, potential of intranasal drug delivery, mechanisms of drug transport to brain, its advantages and limitations, novel intranasal formulations, marketed products, factors affecting nose to brain transport, formulation consideration of intranasal products and the future perspectives of CNS targeting via intranasal drug administration.
治疗神经疾病的主要障碍之一是大多数药物缺乏逃避血脑屏障的能力。在所有绕过血脑屏障的新方法中，经鼻脑转运是最符合患者意愿、最非侵入性和最有效的方法。它通过鼻腔中存在的三叉神经和嗅觉神经将药物直接输送到中枢神经系统。本文重点介绍鼻腔的解剖和生理学、经鼻给药的潜力、药物向脑转运的机制、其优点和局限性、新型经鼻制剂、上市产品、影响经鼻向脑转运的因素、经鼻产品的制剂考虑以及通过经鼻给药靶向中枢神经系统的未来前景。
