Bottermann P, Zilker T, Ermler R, Paterek K, von Stransky B
Klin Wochenschr. 1978 Oct 15;56(20):1029-32. doi: 10.1007/BF01476668.
Intravenous glucose tolerance tests were performed in 10 patients with acute virus hepatitis. The assimilation coefficient of glucose and the level of insulin and C-peptide in serum were determined before and in the course of the glucose tolerance tests. In comparison to healthy normal weight persons C-peptide concentration in patients with acute hepatitis increased twice as high whereas the pattern of insulin secretion did not differ significantly. The higher levels of C-peptide indicate an increase of the beta-cell secretion in acute hepatitis. One could suppose an increased hepatic destruction of insulin in acute hepatitis, because there is no significant difference among the insulin levels. More likely, there is a reactive increase of secretion of the beta-cell due to a reduction of insulin sensitivity and this is indicated much better by C-peptide- than insulin levels because of the longer half live of the the C-peptide molecule.
对10例急性病毒性肝炎患者进行了静脉葡萄糖耐量试验。在葡萄糖耐量试验前及试验过程中测定了葡萄糖同化系数以及血清胰岛素和C肽水平。与健康正常体重者相比，急性肝炎患者的C肽浓度升高了两倍，而胰岛素分泌模式无显著差异。较高的C肽水平表明急性肝炎时β细胞分泌增加。可以推测急性肝炎时肝脏对胰岛素的破坏增加，因为胰岛素水平之间无显著差异。更有可能的是，由于胰岛素敏感性降低，β细胞分泌反应性增加，而由于C肽分子半衰期较长，C肽水平比胰岛素水平更能说明这一点。
