Pinget M, Demangeat C, Comte F, Brogard J M, Jacques C, Sapin R, Dorner M
Ann Endocrinol (Paris). 1980 Sep-Oct;41(5):399-414.
Insulin secretion is assessed by simultaneous radioimmunological assay of insulin (R.I.I.) and C-peptide (R.I.C.P.) levels under basal conditions, and after stimulation by oral or intravenous glucose administration. Subjects with abnormal glucose tolerance demonstrate an increase in the ratios R.I.C.P. divided by glucose and R.I.C.P. divided by R.I.I. after fasting, increase in R.I.I. and R.I.C.P. occurring later and lasting longer after glucose loading. These anomalies are observed in both obese subjects and those with normal body weights. Simultaneous determination of R.I.I. and R.I.C.P. levels appears of value in a limited number of cases where glucose loading tests do not supply precise information on the quality of glucose tolerance. Obese subjects, in whom abnormal hyperglycemia levels provoked by oral glucose are observed, but in whom the peripheral glucose assimilation coefficient is normal, can be considered to be non-diabetic as shown by the levels of R.I.I. and R.I.C.P. and more particularly by the molar ratio R.I.C.P. divided by R.I.I.
通过在基础条件下以及口服或静脉注射葡萄糖刺激后，同时采用放射免疫分析法测定胰岛素（R.I.I.）和C肽（R.I.C.P.）水平来评估胰岛素分泌。糖耐量异常的受试者在空腹后，R.I.C.P.除以葡萄糖以及R.I.C.P.除以R.I.I.的比值会升高，葡萄糖负荷后R.I.I.和R.I.C.P.升高出现得较晚且持续时间更长。在肥胖受试者和体重正常的受试者中均观察到这些异常情况。在有限数量的葡萄糖负荷试验无法提供关于糖耐量质量的精确信息的病例中，同时测定R.I.I.和R.I.C.P.水平似乎具有价值。肥胖受试者口服葡萄糖后会出现异常高血糖水平，但外周葡萄糖同化系数正常，根据R.I.I.和R.I.C.P.水平，尤其是R.I.C.P.除以R.I.I.的摩尔比，可认为这些肥胖受试者无糖尿病。
