Cao-Lei Lei, Saumier Daniel, Fortin Justine, Brunet Alain
Research Center of the Douglas Mental Health University Institute (CIUSSS-ODIM), Montreal, QC, Canada.
Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada.
Front Psychiatry. 2022 Nov 7;13:857087. doi: 10.3389/fpsyt.2022.857087. eCollection 2022.
Epigenetic research in post-traumatic stress disorder (PTSD) is essential, given that environmental stressors and fear play such a crucial role in its development. As such, it may provide a framework for understanding individual differences in the prevalence of the disorder and in treatment response. This paper reviews the epigenetic markers associated with PTSD and its treatment, including candidate genes and epigenome-wide studies. Because the etiopathogenesis of PTSD rests heavily on learning and memory, we also draw upon animal neuroepigenetic research on the acquisition, update and erasure of fear memory, focusing on the mechanisms associated with memory reconsolidation. Reconsolidation blockade (or impairment) treatment in PTSD has been studied in clinical trials and, from a neurological perspective, may hold promise for identifying epigenetic markers of successful therapy. We conclude this paper by discussing several key considerations and challenges in epigenetic research on PTSD in humans.
鉴于环境应激源和恐惧在创伤后应激障碍（PTSD）的发展中起着至关重要的作用，因此PTSD的表观遗传学研究至关重要。因此，它可能为理解该疾病患病率和治疗反应的个体差异提供一个框架。本文综述了与PTSD及其治疗相关的表观遗传标记，包括候选基因和全表观基因组研究。由于PTSD的病因学在很大程度上依赖于学习和记忆，我们还借鉴了动物神经表观遗传学研究中关于恐惧记忆的获取、更新和消除，重点关注与记忆重新巩固相关的机制。PTSD的重新巩固阻断（或损伤）治疗已在临床试验中进行了研究，从神经学角度来看，这可能为识别成功治疗的表观遗传标记带来希望。我们通过讨论人类PTSD表观遗传学研究中的几个关键考虑因素和挑战来结束本文。
