Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.
Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
Front Public Health. 2022 Nov 7;10:938272. doi: 10.3389/fpubh.2022.938272. eCollection 2022.
Worldwide, around 18.2% of cervical cancer occurred in China, mainly because of lower screening coverage and screening quality in regional disparities. To assess self-sampling for human papillomavirus (HPV) testing, combined with the internet, as a primary cervical cancer screening (CCS) method in low-resource settings, and to establish an internet-based self-sampling CCS-management model.
The women who participated registered on a CCS website. We recruited 20,136 women, aged 30-59 years, from 13 provinces in China, to perform vaginal self-sampling for HPV testing as a primary CCS, based on the internet. A questionnaire was subsequently used to investigate the acceptability of self-sampling.
Of the 20,103 women with qualified samples, 35.80% lived in remote areas, 37.69% had never undergone CCS, 59.96% were under-screened, and the overall prevalence of a high-risk of HPV was 13.86%. Of 8,136 respondents, 95.97% of women felt that self-sampling was easy to perform, 84.61% had no discomfort when using a self-sampling brush, 62.37% women were more likely to choose self-sampling for CCS in future, and 92.53% were willing to introduce the concept to others around them. The reliability and ease of self-sampling were independent factors influencing selection of self-sampling ( < 0.05).
The Internet-facilitated self-sampling for HPV testing and management model for cervical cancer prevention is feasible and effective. It can be used as a supplement to the conventional screening, particularly in outlying areas with few medical resources, to improve the coverage of CCS.
https://www.chictr.org.cn, identifier: ChiCTR2000032331.
全世界范围内，约 18.2%的宫颈癌发生在中国，主要是因为在地域差异下，筛查覆盖率和筛查质量较低。本研究旨在评估互联网辅助下的人乳头瘤病毒（HPV）自我采样作为一种在资源匮乏地区进行宫颈癌初筛（CCS）的方法，并建立一种基于互联网的自我采样 CCS 管理模式。
参与的妇女在 CCS 网站上注册。我们从中国 13 个省份招募了 20136 名年龄在 30-59 岁的妇女，通过互联网对其进行 HPV 自我采样检测，作为初筛方法。随后使用问卷对自我采样的可接受性进行调查。
在 20103 名有合格样本的妇女中，35.80%来自偏远地区，37.69%从未接受过 CCS，59.96%为未筛查人群，高危型 HPV 总患病率为 13.86%。在 8136 名受访者中，95.97%的女性认为自我采样易于实施，84.61%在使用采样刷时没有不适感，62.37%的女性在未来更倾向于选择自我采样进行 CCS，92.53%的女性愿意向周围人介绍这一概念。自我采样的可靠性和易用性是影响自我采样选择的独立因素（<0.05）。
互联网辅助 HPV 自我采样和宫颈癌防治管理模式是可行且有效的。它可以作为传统筛查的补充，特别是在医疗资源匮乏的偏远地区，以提高 CCS 的覆盖率。
https://www.chictr.org.cn，标识符：ChiCTR2000032331。
