Wang Changfeng, Sun Jiali, Guo Lei, Song Dan, Zhang Xin, Liu Zhuang, Wang Liang
Department of Vascular Anomalies and Interventional Radiology, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Front Oncol. 2022 Nov 8;12:1014465. doi: 10.3389/fonc.2022.1014465. eCollection 2022.
Intralesional injection of lauromacrogol has proven to be an efficient treatment method for infantile hemangioma. This study aims to explore a novel injection therapy and evaluate its efficacy and complications.
The medical records of 368 children with infantile hemangioma who received a lauromacrogol injection from January 2021 to April 2022 were retrospectively analyzed. All patients were reviewed every 4 weeks, and their condition was assessed according to symptoms and medical records. The patient's age, lesion type, location, size and thickness, lesion photographs, ultrasound, and complications were recorded.
Among the 368 infants who accept sclerotherapy with lauromacrogol, 226(61.4%)achieved excellent regression. In total, 108(29.4%)cases achieved good regression. 24(6.5%)achieved complete moderate regression. 10(2.7%)achieved poor regression. The reported incidence of adverse events was 4.9% and severe complications were not observed. Before and after three courses of treatment, the median vascular endothelial growth factor levels were 104.12 pg/ml and 28.982 pg/ml. There was a significant difference between the two groups (P=0.0043).
The results showed that this novel injection therapy a safe and effective treatment method. The therapy accelerated the regression of infantile hemangiomas without serious complications.
已证实聚桂醇瘤内注射是治疗婴幼儿血管瘤的一种有效方法。本研究旨在探索一种新型注射疗法并评估其疗效及并发症。
回顾性分析2021年1月至2022年4月接受聚桂醇注射治疗的368例婴幼儿血管瘤患儿的病历。所有患者每4周复查一次，根据症状和病历评估病情。记录患者的年龄、病变类型、位置、大小和厚度、病变照片、超声检查结果及并发症情况。
在接受聚桂醇硬化治疗的368例婴儿中，226例（61.4%）达到极佳消退效果。总计108例（29.4%）达到良好消退效果。24例（6.5%）达到中度完全消退。10例（2.7%）消退效果较差。报告的不良事件发生率为4.9%，未观察到严重并发症。三个疗程治疗前后，血管内皮生长因子水平中位数分别为104.12 pg/ml和28.982 pg/ml。两组间差异有统计学意义（P = 0.0043）。
结果表明，这种新型注射疗法是一种安全有效的治疗方法。该疗法加速了婴幼儿血管瘤的消退，且无严重并发症。
