Department of Vascular Anomalies and Interventional Radiology, Qilu Children'sHospital of Shandong University, Room 23976, Jingshi Road, Jinan City, Shandong prov. CN 250022.
Department of Stomatology, Qilu Children'sHospital of Shandong University, Room 23976, Jingshi Road, Jinan City, Shandong prov. CN 250022.
J Vasc Interv Radiol. 2021 Feb;32(2):293-298. doi: 10.1016/j.jvir.2020.09.029. Epub 2020 Nov 18.
To report the effectiveness and safety of transcatheter arterial sclerosing embolization (TASE) for the treatment of parotid infantile hemangiomas that did not respond appreciably to propranolol.
A total of 21 infants (12 male and 9 female) with large propranolol-resistant infantile hemangiomas in the parotid region were enrolled in this study. During TASE, the feeding arteries of the lesions were embolized using pingyangmycin-lipiodol emulsion and polyvinyl alcohol particles (300-500 μm) to reduce the blood flow rate. All children were followed up as outpatients at 2 weeks and monthly thereafter. The curative effect was evaluated at the 1- and 3-month follow-up visits.
Nine lesions were located on the right side of the parotid gland, whereas 12 were located on the left side. The feeding arteries in all patients originated from branches of the external carotid artery. TASE was technically successful in all patients. The mean (± SD) maximal diameter of the hemangiomas significantly decreased from 6.50 cm ± 2.28 before treatment to 3.56 cm ± 1.84 at 1 month after TASE (P <. 05). Three months after TASE, the mean maximal diameter further significantly decreased to 1.94 cm ± 1.58 (P <. 05). During the follow-up period, 16 cases were rated as excellent and 5 as good; no recurrence or serious complications were noted. Minor side effects, such as slight pain, mild fever, and tissue swelling, were observed.
TASE significantly decreased the size of the parotid hemangiomas with minor side effects during a short follow-up period.
报道经导管动脉硬化栓塞术（TASE）治疗对普萘洛尔治疗反应不佳的腮腺婴幼儿血管瘤的有效性和安全性。
本研究共纳入 21 例腮腺区大的普萘洛尔耐药性婴幼儿血管瘤患儿（男 12 例，女 9 例）。在 TASE 过程中，使用平阳霉素-碘油乳剂和聚乙烯醇颗粒（300-500μm）栓塞病变的供养动脉，以降低血流速度。所有患儿均在 2 周后及此后每月进行门诊随访。在 1 个月和 3 个月的随访中评估疗效。
9 个病灶位于腮腺右侧，12 个病灶位于左侧。所有患者的供养动脉均发自颈外动脉分支。所有患者均成功实施 TASE。治疗前，血管瘤最大直径的平均值（±标准差）为 6.50cm±2.28cm，治疗后 1 个月显著减小至 3.56cm±1.84cm（P<.05）。TASE 后 3 个月，最大直径进一步显著减小至 1.94cm±1.58cm（P<.05）。在随访期间，16 例评为优秀，5 例评为良好；未发现复发或严重并发症。仅观察到轻微疼痛、轻度发热和组织肿胀等轻微副作用。
在短期随访期间，TASE 显著缩小了腮腺血管瘤的大小，且副作用较小。
