血清 25-羟维生素 D 浓度异常低下的慢性或蛋白丢失性肠病犬的血清镁、钙和甲状旁腺浓度之间的关系。
Relationship between serum magnesium, calcium, and parathyroid concentrations in dogs with abnormally low serum 25-hydroxyvitamin D concentration and chronic or protein-losing enteropathy.
机构信息
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
出版信息
J Vet Intern Med. 2023 Jan;37(1):101-109. doi: 10.1111/jvim.16595. Epub 2022 Nov 25.
BACKGROUND
The relationship between the development of SHPT and ionized magnesium (iMg) concentrations in blood of dogs with chronic gastrointestinal (GI) disease and abnormally low 25(OH)D is undefined.
OBJECTIVES
Evaluate relationships between ionized magnesium (iMg), PTH, ionized calcium (iCa), and 25(OH)D in dogs with chronic enteropathy (CE) with or without protein-losing enteropathy (PLE) and abnormal 25(OH)D. Determine whether dogs with CE or PLE, decreased 25(OH)D and SHPT have differences in iMg, iCa, or 25(OH)D when compared to dogs that do not have SHPT.
ANIMALS
Fifty dogs with CE +/- PLE and abnormally low serum 25(OH)D.
METHODS
Retrospective search of submissions database at a veterinary diagnostic laboratory for vitamin D profiles submitted in years 2017 to 2020. Cases were excluded if supplemented with Ca, Mg, or vitamin D. Spearman correlation was performed to evaluate relationships between iMg, PTH, 25(OH)D, and iCa. Ionized Mg, iCa, and 25(OH)D concentrations were compared between dogs with SHPT and those with normal PTH concentrations.
RESULTS
Concentrations of iMg were weakly negatively correlated with PTH (rho, -.31; P = .03), and weakly positively correlated with serum 25(OH)D (rho, .34, P = .02) and iCa (rho, .42, P = .003). Ionized magnesium concentrations were lower in dogs with abnormally low 25(OH)D and SHPT compared to dogs with abnormally low 25(OH)D and normal parathyroid hormone concentrations (P = .01).
CONCLUSIONS AND CLINICAL IMPORTANCE
Hypomagnesemia might contribute to alterations in iCa and parathyroid hormone in dogs with CE +/- PLE and abnormally low 25(OH)D.
背景
患有慢性胃肠道（GI）疾病和异常低的 25（OH）D 的犬 SHPT 的发展与血中离子化镁（iMg）浓度之间的关系尚不清楚。
目的
评估患有慢性肠炎（CE）和/或伴有蛋白丢失性肠炎（PLE）且 25（OH）D 异常的犬的离子化镁（iMg）、甲状旁腺激素（PTH）、离子化钙（iCa）和 25（OH）D 之间的关系。确定患有 CE 或 PLE、低 25（OH）D 和 SHPT 的犬与无 SHPT 的犬相比，其 iMg、iCa 或 25（OH）D 是否存在差异。
动物
50 只患有 CE +/- PLE 且血清 25（OH）D 异常低的犬。
方法
在兽医诊断实验室的提交数据库中进行了 2017 年至 2020 年维生素 D 图谱的回顾性检索。如果犬补充钙、镁或维生素 D，则将其排除在外。采用 Spearman 相关分析评估 iMg、PTH、25（OH）D 和 iCa 之间的关系。比较甲状旁腺功能亢进犬与甲状旁腺激素浓度正常的犬的 iMg、iCa 和 25（OH）D 浓度。
结果
iMg 浓度与 PTH 呈弱负相关（rho，-0.31；P = 0.03），与血清 25（OH）D（rho，0.34，P = 0.02）和 iCa（rho，0.42，P = 0.003）呈弱正相关。与甲状旁腺激素浓度正常的异常低 25（OH）D 犬相比，异常低 25（OH）D 和甲状旁腺功能亢进犬的 iMg 浓度较低（P = 0.01）。
结论和临床意义
患有 CE +/- PLE 和异常低 25（OH）D 的犬可能存在低镁血症，从而导致 iCa 和甲状旁腺激素发生变化。
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