Oishi Nene, Ohta Hiroshi, Tamura Masahiro, Hanazono Kiwamu, Miyoshi Kenjiro, Yokoyama Nozomu, Shinbo Genya
Companion Animal Internal Medicine, Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
J Vet Intern Med. 2025 May-Jun;39(3):e70098. doi: 10.1111/jvim.70098.
Inflammatory protein-losing enteropathy (iPLE) is thought to be associated with a hypercoagulable state and may predispose dogs to thromboembolism (TE). However, little information is available regarding the prevalence of TE in dogs with iPLE.
Estimate the prevalence of TE in dogs with iPLE and collect clinical and clinicopathologic data from dogs with iPLE with and without TE.
Twenty-two client-owned dogs with iPLE.
Prospective, descriptive study. Dogs definitively diagnosed with iPLE based on standard diagnostic criteria and histopathology were recruited between January 2019 and February 2024. At the time of gastrointestinal endoscopic examination, dogs with iPLE underwent thoracic and abdominal computed tomography angiography to detect TE. Clinical (e.g., clinical severity, use of corticosteroids) and clinicopathologic (e.g., albumin concentration, coagulation parameters) data were collected from dogs with iPLE with and without TE.
Thromboembolism was found in 3/22 dogs (13.6%, 95% confidence interval: 2.9-34.9) with iPLE. The three dogs with iPLE and TE had thrombi in the left external iliac artery, pulmonary artery of the right caudal lobe, and main portal vein, respectively. The dogs with thrombi in the left external iliac artery or pulmonary artery did not show any clinical signs associated with TE, whereas the dog with portal vein thrombosis had transudative peritoneal effusion.
We estimated the prevalence of TE in dogs with iPLE. In dogs with iPLE, TE could be underestimated because some affected dogs have subclinical TE.
炎症性蛋白丢失性肠病（iPLE）被认为与高凝状态有关，可能使犬易患血栓栓塞（TE）。然而，关于iPLE犬中TE的患病率，目前可用信息较少。
估计iPLE犬中TE的患病率，并收集患有和未患有TE的iPLE犬的临床和临床病理数据。
22只客户拥有的患有iPLE的犬。
前瞻性描述性研究。根据标准诊断标准和组织病理学确诊为iPLE的犬于2019年1月至2024年2月招募。在胃肠内镜检查时，iPLE犬接受胸部和腹部计算机断层血管造影以检测TE。收集患有和未患有TE的iPLE犬的临床（如临床严重程度、皮质类固醇的使用）和临床病理（如白蛋白浓度、凝血参数）数据。
22只iPLE犬中有3只（13.6%，95%置信区间：2.9 - 34.9）发现血栓栓塞。三只患有iPLE和TE的犬分别在左髂外动脉、右尾叶肺动脉和门静脉主干有血栓。左髂外动脉或肺动脉有血栓的犬未表现出与TE相关的任何临床症状，而门静脉血栓形成的犬有漏出性腹腔积液。
我们估计了iPLE犬中TE的患病率。在iPLE犬中，TE可能被低估，因为一些受影响的犬有亚临床TE。
