Laboratory of Anatomy of Domestic Animals, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Int J Mol Sci. 2022 Nov 20;23(22):14417. doi: 10.3390/ijms232214417.
Alzheimer's disease (AD) is a global concern and has become a major public health event affecting human health. Insulin is a metabolic hormone secreted mainly by the peripheral tissue pancreas. In recent years, more and more evidence has proved that insulin regulates various functions of the brain. The hippocampus, one of the earliest brain regions affected by AD, is widely distributed with insulin receptors. Studies have shown that type 2 diabetes mellitus, characterized by insulin resistance, is closely related to AD, which has drawn extensive attention to the relationship between hippocampal insulin signaling and AD. Therefore, we provide an overview of intranasal insulin administration on memory and its underlying mechanism. We also highlight the molecular link between hippocampal insulin resistance and AD and provide a theoretical basis for finding new therapeutic targets for AD in clinical practice.
阿尔茨海默病（AD）是一个全球性的问题，已经成为影响人类健康的主要公共卫生事件。胰岛素是一种主要由外周组织胰腺分泌的代谢激素。近年来，越来越多的证据证明胰岛素调节大脑的各种功能。海马体是受 AD 影响最早的大脑区域之一，广泛分布着胰岛素受体。研究表明，以胰岛素抵抗为特征的 2 型糖尿病与 AD 密切相关，这引起了人们对海马胰岛素信号与 AD 之间关系的广泛关注。因此，我们就鼻腔内给予胰岛素对记忆的影响及其潜在机制进行综述。我们还强调了海马胰岛素抵抗与 AD 之间的分子联系，并为在临床实践中寻找 AD 的新治疗靶点提供了理论依据。
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