Rubinstein L, Moguilevsky J, Leiderman S
Obstet Gynecol. 1978 Nov;52(5):571-4.
This study was designed to assess the effect of long-term treatment with three combined oral contraceptives (OC) on the gonadotropin response to LHRH. The release of LH and FSH after a single 50-microgram dose of LHRH was studied from Days 11 to 14 of treatment and Days 2 and 3 after discontinuation of the treatment. The responses were compared with controls during the luteal phase (Days 16 to 19) of the menstrual cycle. LH and FSH baseline levels and release after LHRH injection were markedly depressed in women on OC treatment. The patterns of gonadotropin response after LHRH, however, were similar to the responses during the luteal phase. Following discontinuation of OC treatment, the basal levels of LH and FSH and the response to LHRH continued to be depressed, with a further decrease in the FSH release. These results indicate that treatment with combined OC exert a significant depression on the release of gonadotropins.
本研究旨在评估三种复方口服避孕药（OC）长期治疗对促性腺激素对促黄体生成素释放激素（LHRH）反应的影响。在治疗的第11至14天以及治疗中断后的第2和3天，研究了单次50微克剂量LHRH后促黄体生成素（LH）和促卵泡生成素（FSH）的释放情况。将这些反应与月经周期黄体期（第16至19天）的对照组进行比较。接受OC治疗的女性，LH和FSH的基线水平以及LHRH注射后的释放均明显降低。然而，LHRH后促性腺激素的反应模式与黄体期的反应相似。OC治疗中断后，LH和FSH的基础水平以及对LHRH的反应持续降低，FSH释放进一步减少。这些结果表明，复方OC治疗对促性腺激素的释放有显著抑制作用。
