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病例报告:Sars-CoV-2 对马凡综合征的影响导致急性主动脉夹层。

Case Report: Effects of Sars-CoV-2 on Marfan syndrome with resulting acute aortic dissection.

机构信息

University of Toledo, College of Nursing, 3000 Arlington Avenue, Mail Stop #1026, Toledo, Ohio 43614-2598, United States.

University of Toledo, 3000 Arlington Avenue, Mail Stop #1026, Toledo, Ohio 43614-2598, United States of America.

出版信息

J Vasc Nurs. 2022 Dec;40(4):181-183. doi: 10.1016/j.jvn.2022.09.002. Epub 2022 Sep 22.

Abstract

Marfan syndrome is one of the most common inherited connective tissue disorders that affects the heart, eyes, blood vessels, and bones. It occurs in approximately 1-2 per 10,000 individuals annually. Many patients with Marfan syndrome eventually develop aortic wall abnormalities, often resulting in aortic dilatation, which increases the risk of acute aortic dissection. Recent studies involving SARS-CoV-2 propose that individuals with connective tissue disorders such as Marfan syndrome can have additional associated conditions that could impose a higher risk for morbidity and mortality from SARS-CoV-2. The purpose of this article is to discuss the interrelationship between Marfan Syndrome, Acute Type A Aortic Dissection in a patient with Sars-CoV-2 infection. Pertinent review of these conditions, diagnostic findings, treatment, and the patient's clinical course will be discussed. There is minimal research focused on the connection between this novel virus, Marfan Syndrome, and compounding risk for aortic dissection.

摘要

马凡综合征是一种最常见的遗传性结缔组织疾病,可影响心脏、眼睛、血管和骨骼。每年约有 1-2 人/每 10000 人发病。许多马凡综合征患者最终会出现主动脉壁异常,常导致主动脉扩张,从而增加急性主动脉夹层的风险。最近涉及 SARS-CoV-2 的研究表明,患有马凡综合征等结缔组织疾病的个体可能会出现其他相关病症,这可能会使他们因 SARS-CoV-2 而导致发病率和死亡率上升的风险更高。本文旨在讨论马凡综合征与 SARS-CoV-2 感染患者的急性 A 型主动脉夹层之间的相互关系。将讨论这些病症的相关性、诊断发现、治疗和患者的临床病程。目前针对这种新型病毒、马凡综合征和主动脉夹层复合风险之间的关联,研究很少。

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