Moreno-Andrés Daniel, Holl Kristin, Antonin Wolfram
Institute of Biochemistry and Molecular Cell Biology, Medical School, RWTH Aachen University, Aachen, Germany.
Institute of Biochemistry and Molecular Cell Biology, Medical School, RWTH Aachen University, Aachen, Germany.
Semin Cancer Biol. 2023 Jan;88:1-17. doi: 10.1016/j.semcancer.2022.11.013. Epub 2022 Nov 24.
The nucleus undergoes dramatic structural and functional changes during cell division. With the entry into mitosis, in human cells the nuclear envelope breaks down, chromosomes rearrange into rod-like structures which are collected and segregated by the spindle apparatus. While these processes in the first half of mitosis have been intensively studied, much less is known about the second half of mitosis, when a functional nucleus reforms in each of the emerging cells. Here we review our current understanding of mitotic exit and nuclear reformation with spotlights on the links to cancer biology.
在细胞分裂过程中，细胞核会经历显著的结构和功能变化。随着进入有丝分裂，在人类细胞中核膜解体，染色体重新排列成棒状结构，这些结构由纺锤体装置收集并分离。虽然有丝分裂前半段的这些过程已得到深入研究，但对于有丝分裂后半段，即每个新出现的细胞中功能性细胞核重新形成的过程，人们了解得要少得多。在这里，我们回顾了我们目前对有丝分裂退出和细胞核重新形成的理解，并重点关注与癌症生物学的联系。
