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甲状腺癌转移至肾脏,最初表现为双侧肾脏肿块:一例罕见病例报告并文献复习。

Metastatic Thyroid Carcinoma to the Kidneys Presenting Initially as Bilateral Renal Masses: A Rare Case Report and Literature Review.

机构信息

Department of Pathology and Laboratory Medicine, Mayo Clinic College of Medicine and Science, Jacksonville, FL, USA.

The Bolles High School, Jacksonville, FL, USA.

出版信息

Int J Surg Pathol. 2023 Aug;31(5):795-800. doi: 10.1177/10668969221138860. Epub 2022 Nov 27.

Abstract

Thyroid cancers exist in multiple forms. Papillary and follicular carcinomas of the thyroid are often referred to as well-differentiated thyroid cancers. Well-differentiated thyroid cancers rarely present as a distant metastatic cancer on initial diagnosis. Papillary thyroid cancer tends to have a good prognosis; however, if distant metastasis of PTC is present, there is usually a poor clinical outcome with a less favorable prognosis. In this study, we report a 90-year-old female who presented with right-sided abdominal discomfort. A renal ultrasound revealed bilateral upper pole renal masses. A percutaneous biopsy was ordered, and the microscopic examination revealed bilateral renal metastasis with a follicular variant of papillary thyroid carcinoma. The patient underwent thyroidectomy and sustained radiation therapy for her bilateral renal metastases. She died 6 years after her initial diagnosis, due to sepsis. This is the second study in literature to report bilateral renal metastasis of follicular variant of papillary thyroid cancer.

摘要

甲状腺癌有多种类型。甲状腺乳头状癌和滤泡状癌通常被称为分化良好的甲状腺癌。分化良好的甲状腺癌在初始诊断时很少表现为远处转移性癌症。甲状腺乳头状癌的预后通常较好;然而,如果存在 PTC 的远处转移,通常临床结局较差,预后也较差。在本研究中,我们报告了一例 90 岁女性,表现为右侧腹部不适。肾脏超声显示双侧肾上极肿块。行肾穿刺活检,显微镜检查显示双侧肾转移,伴甲状腺滤泡状癌。患者行甲状腺切除术,并对双侧肾转移灶进行放疗。她在最初诊断后的 6 年内死于脓毒症。这是文献中第二例报告的甲状腺滤泡状癌的双侧肾转移病例。

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