Corby D G
Pediatrics. 1978 Nov;62(5 Pt 2 Suppl):930-7.
Recent surveys of prenatal drug consumption indicate that aspirin is the most frequently consumed drug in pregnancy. Over the past several years, numerous reports have suggested a possible association between prenatal aspirin ingestion and adverse effects in the pregnant woman and her developing fetus. This review summarizes the available experimental animal and human epidemiological data on the possible teratogenicity of aspirin, its effects on fetal lethality, its effects on the duration of pregnancy and parturition, and its ability to alter hemostatic mechanisms in both the mother and newborn. From an analysis of the data, it appears that, although direct conclusive evidence of adverse effects in humans is lacking, a potential hazard does exist and thus "the indiscriminate use of aspirin during pregnancy is contraindicated."
近期关于孕期药物使用情况的调查表明，阿司匹林是孕期最常使用的药物。在过去几年中，大量报告指出，孕期服用阿司匹林可能与对孕妇及其发育中的胎儿产生不良影响有关。这篇综述总结了现有的实验动物和人类流行病学数据，这些数据涉及阿司匹林可能的致畸性、对胎儿致死率的影响、对孕期和分娩时长的影响，以及其改变母亲和新生儿止血机制的能力。从数据分析来看，尽管缺乏人类不良影响的直接确凿证据，但潜在风险确实存在，因此“孕期禁忌无差别使用阿司匹林”。
