Grut Viktor, Biström Martin, Salzer Jonatan, Stridh Pernilla, Lindam Anna, Alonso-Magdalena Lucia, Andersen Oluf, Jons Daniel, Gunnarsson Martin, Vrethem Magnus, Hultdin Johan, Sundström Peter
Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Mult Scler J Exp Transl Clin. 2022 Nov 22;8(4):20552173221139768. doi: 10.1177/20552173221139768. eCollection 2022 Oct-Dec.
C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS).
To assess CRP as a risk factor for MS.
Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837 individuals who later developed MS and 984 matched controls. The risk of developing MS was analysed by conditional logistic regression on -scored CRP values.
Levels of CRP were not associated with MS risk.
We found no association between CRP levels and risk of MS development.
C反应蛋白（CRP）是全身炎症的标志物。有研究表明，年轻人中CRP水平升高可降低患多发性硬化症（MS）的风险。
评估CRP作为MS的危险因素。
采用高敏免疫分析法测量了837例后来患MS的个体以及984例匹配对照的生物样本库样本中的CRP水平。通过对CRP评分值进行条件逻辑回归分析患MS的风险。
CRP水平与MS风险无关。
我们发现CRP水平与MS发病风险之间无关联。
