Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.
Clinical Chemistry, Department of Medical Biosciences, Umeå University, Umeå, Sweden.
Mult Scler. 2021 Jan;27(1):19-27. doi: 10.1177/1352458520905033. Epub 2020 Feb 7.
Obesity early in life has been linked to increased risk of developing multiple sclerosis (MS). Leptin and insulin are both associated with obesity, making them suitable candidates for investigating this connection.
To determine if leptin and insulin are risk factors for relapsing-remitting multiple sclerosis (RRMS).
In this nested case-control study using blood samples from Swedish biobanks, we compared concentrations of leptin and insulin in 649 individuals who later developed RRMS with 649 controls matched for biobank, sex, age and date of sampling. Only pre-symptomatically drawn samples from individuals below the age of 40 years were included. Conditional logistic regression was performed on -scored values to calculate odds ratios (ORs) with 95% confidence intervals (CIs).
A 1-unit leptin -score increase was associated with increased risk of MS in individuals younger than 20 years (OR = 1.4, 95% CI = 1.1-1.9) and in all men (OR = 1.4, 95% CI = 1.0-2.0). In contrast, for women aged 30-39 years, there was a lower risk of MS with increased leptin levels (OR = 0.74, 95% CI = 0.54-1.0) when adjusting for insulin levels.
We show that the pro-inflammatory adipokine leptin is a risk factor for MS among young individuals.
生命早期肥胖与多发性硬化症（MS）风险增加有关。瘦素和胰岛素都与肥胖有关，因此它们是研究这种联系的合适候选物。
确定瘦素和胰岛素是否是复发性缓解型多发性硬化症（RRMS）的危险因素。
在这项使用瑞典生物库血液样本进行的巢式病例对照研究中，我们比较了 649 名后来发展为 RRMS 的个体与 649 名按生物库、性别、年龄和采样日期匹配的对照者的瘦素和胰岛素浓度。仅纳入年龄在 40 岁以下的个体的无症状前样本。使用条件逻辑回归对 -评分值进行分析，以计算比值比（OR）及其 95％置信区间（CI）。
在年龄小于 20 岁的个体（OR=1.4，95％CI=1.1-1.9）和所有男性（OR=1.4，95％CI=1.0-2.0）中，瘦素 -评分每增加 1 单位，MS 的风险就会增加。相比之下，在调整胰岛素水平后，对于 30-39 岁的女性，随着瘦素水平的升高，MS 的风险降低（OR=0.74，95％CI=0.54-1.0）。
我们表明，促炎脂肪因子瘦素是年轻个体中 MS 的危险因素。
