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比较转录组分析揭示了雄性狮头鹅季节性繁殖的候选基因。

Comparative transcriptomic analysis reveals candidate genes for seasonal breeding in the male Lion-Head goose.

机构信息

Guangdong Provincial Key Laboratory of Waterfowl Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, P. R. China.

MRC Human Genetics Unit at Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

出版信息

Br Poult Sci. 2023 Apr;64(2):157-163. doi: 10.1080/00071668.2022.2152651. Epub 2023 Feb 8.

Abstract
  1. Due to seasonal breeding, geese breeds from Southern China have low egg yield. The genetic makeup underlying performance of local breeds is largely unknown, and few studies have investigated this problem. This study integrated 21 newly generated and 50 publicly existing RNA-seq libraries, representing the hypothalamus, pituitary and testis, to identify candidate genes and importantly related pathways associated with seasonal breeding in male Lion-Head geese.2. In total, 19, 119 and 302 differentially expressed genes (DEGs) were detected in the hypothalamus, pituitary and testis, respectively, of male Lion-Head geese between non-breeding and breeding periods. These genes were significantly involved in the neuropeptide signalling pathway, gland development, neuroactive ligand-receptor interaction, JAK-STAT signalling pathway, cAMP signalling pathway, PI3K-Akt signalling pathway and Foxo signalling pathway.3. By integrating another 50 RNA-seq samples 4, 18 and 40 promising DEGs were confirmed in hypothalamus, pituitary and testis, respectively.4. genes were identified as having important roles in the development of testis between non-breeding and breeding periods of male Lion-Head geese.
摘要
  1. 由于季节性繁殖,来自中国南方的鹅产蛋量较低。本地品种表现背后的遗传构成在很大程度上是未知的,很少有研究调查这个问题。本研究整合了 21 个新生成和 50 个公开存在的 RNA-seq 文库,代表下丘脑、垂体和睾丸,以鉴定与雄性狮头鹅季节性繁殖相关的候选基因和重要途径。2. 总共,在非繁殖期和繁殖期之间,雄性狮头鹅的下丘脑、垂体和睾丸中分别检测到 19、119 和 302 个差异表达基因(DEGs)。这些基因显著参与神经肽信号通路、腺体发育、神经活性配体-受体相互作用、JAK-STAT 信号通路、cAMP 信号通路、PI3K-Akt 信号通路和 Foxo 信号通路。3. 通过整合另外 50 个 RNA-seq 样本,分别在下丘脑、垂体和睾丸中确认了 18 和 40 个有前途的 DEGs。4. 鉴定出 4 个基因在雄性狮头鹅非繁殖期和繁殖期睾丸发育过程中具有重要作用。

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