Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Alzheimers Dement. 2023 May;19(5):2047-2055. doi: 10.1002/alz.12888. Epub 2022 Nov 29.
We determined associations of total and regional adiposity with incident dementia among older adults.
Within the population-based Rotterdam Study, adiposity was measured as total, android, and gynoid fat mass using dual-energy X-ray absorptiometry in 3408 men and 4563 women, every 3 to 6 years between 2002 and 2016. Incident dementia was recorded until 2020.
Higher adiposity measures were associated with a decreased risk of dementia in both sexes. After excluding the first 5 years of follow-up, only the association of gynoid fat among women remained significant (hazard ratio 0.85 [95% confidence interval 0.75-0.97] per standard deviation increase). No major differences in trajectories of adiposity measures were observed between dementia cases and dementia-free controls.
Higher total and regional fat mass related to a decreased risk of dementia. These results may be explained by reverse causality, although a protective effect of adiposity cannot be excluded.
Total and regional adiposity were assessed using dual-energy X-ray absorptiometry scans in 7971 older adults. All adiposity measures were associated with a decreased risk of dementia. The results suggest a beneficial effect of gynoid fat on the risk of dementia in women. Reverse causation and competing risk may explain these inverse associations.
我们旨在确定全身和局部肥胖与老年人痴呆症发病之间的关联。
在基于人群的鹿特丹研究中，使用双能 X 射线吸收法在 3408 名男性和 4563 名女性中测量了总脂肪量、腹型脂肪量和臀型脂肪量，随访时间为 2002 年至 2016 年，每 3 至 6 年一次。记录痴呆症发病情况，直至 2020 年。
在两性中，更高的肥胖指标与痴呆症风险降低相关。在排除随访的前 5 年后，只有女性臀型脂肪与痴呆症之间的关联仍然显著（每标准差增加的风险比为 0.85[95%置信区间 0.75-0.97]）。在痴呆症病例和无痴呆症对照者之间，未观察到肥胖指标轨迹的明显差异。
全身和局部脂肪量越高，痴呆症风险越低。这些结果可能可以用反向因果关系来解释，尽管不能排除肥胖的保护作用。
在 7971 名老年人中使用双能 X 射线吸收法评估了全身和局部肥胖。所有肥胖指标均与痴呆症风险降低相关。这些结果表明臀型脂肪对女性痴呆症风险具有有益影响。反向因果关系和竞争风险可能解释了这些相反的关联。
