Suo Xiaowen, Wang Yiming, Xue Fuzhong
Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Wenhuaxi Road, P.O. Box 10044, Jinan 250012, China.
Department of Biotechnology, College of Life Sciences, Shandong Agricultural University, Taian 271018, China.
Healthcare (Basel). 2025 May 29;13(11):1286. doi: 10.3390/healthcare13111286.
The weight-adjusted waist index (WWI), a novel measure of abdominal obesity independent of overall weight, has shown promise in assessing health risks. However, its relationship with dementia remains unclear. This study investigates the association between the WWI and dementia risk in British older adults. : Employing data from the United Kingdom Biobank, we conducted a prospective cohort study focusing on 155,683 elderly participants. Multivariable logistic regression models were employed to investigate the linear association between the WWI and all-cause dementia. Restricted cubic spline analysis was used to evaluate non-linear relationships, while subgroup analyses and interaction tests were performed to examine the stability of findings across different populations. : Among participants (mean age: 63.2 years; 52.2% male), 3211 dementia cases were identified during 13.1 years of follow-up (2.06% prevalence). The analysis revealed a significant inverse relationship between the WWI and dementia risk. In fully adjusted models, higher WWI was associated with a reduced risk of dementia (β = -0.274, < 0.001). When the WWI was categorized into quartiles, participants in the highest quartile exhibited a 47% lower risk of dementia compared to those in the lowest quartile. This inverse association was particularly pronounced among non-current smokers ( < 0.05 for interaction). Restricted cubic spline analysis confirmed a non-linear relationship, with the protective effect of the WWI becoming more evident at higher values. : The WWI is inversely associated with dementia risk in British older adults. These findings reveal that the WWI may serve as a potential predictor for dementia risk, highlighting its potential in risk stratification and prevention strategies.
体重调整腰围指数（WWI）是一种独立于总体重的腹部肥胖新指标，在评估健康风险方面已显示出前景。然而，其与痴呆症的关系仍不明确。本研究调查了英国老年人中WWI与痴呆症风险之间的关联。：利用英国生物银行的数据，我们进行了一项前瞻性队列研究，重点关注155683名老年参与者。采用多变量逻辑回归模型研究WWI与全因性痴呆之间的线性关联。使用受限立方样条分析来评估非线性关系，同时进行亚组分析和交互作用检验，以检验不同人群中研究结果的稳定性。：在参与者（平均年龄：63.2岁；52.2%为男性）中，在13.1年的随访期间确定了3211例痴呆症病例（患病率为2.06%）。分析显示WWI与痴呆症风险之间存在显著的负相关关系。在完全调整的模型中，较高的WWI与较低的痴呆症风险相关（β=-0.274，<0.001）。当将WWI分为四分位数时，最高四分位数的参与者与最低四分位数的参与者相比，痴呆症风险降低了47%。这种负相关在非当前吸烟者中尤为明显（交互作用<0.05）。受限立方样条分析证实了非线性关系，WWI的保护作用在较高值时变得更加明显。：在英国老年人中，WWI与痴呆症风险呈负相关。这些发现表明，WWI可能作为痴呆症风险的潜在预测指标，突出了其在风险分层和预防策略中的潜力。
