Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pathology, School of Medicine , Razi Hospital, Imam Khomeini Hospital , Tehran University of Medical Sciences, Tehran, Iran.
Asian Pac J Cancer Prev. 2022 Nov 1;23(11):3735-3741. doi: 10.31557/APJCP.2022.23.11.3735.
To determine the occurrence of Activated Leukocyte Cell Adhesion Molecule (ALCAM) and its predictive factors in patients with oral squamous cell carcinoma (OSCC).
This cross sectional study was concocted on 102 patients with OSCC referred to Imam Khomeini Hospital of Tehran during 1997-2015. The data collection tool a checklist consisted of demographic and pathologic (lymph node involvement, differentiation, tumor size and tumor location) characteristics which extracted from patients' medical records. To evaluate ALCAM, a new sample of tumor tissue was prepared from archive. Finally, the multivariable logistic regression model was used to determine the predictive factors of ALCAM by STATA14.
the number (%) of men and women were 70 (68.6) and 32 (31.4%), respectively. The mean age (S.D) of participants was 61.7 (15.6) years. Of the total samples, 32 (38.2), 19 (18.6), 36 (35.3) and 8 (7.8%) samples were related to the tongue, oral mucosa, skin and lips, respectively. More than half of the tumors had good differentiation and lymph node involvement and 74.5% were ≥20 mm. Also, 79.41% of the samples were positive for the overall incidence of ALCAM. The most important predictors of the overall incidence of ALCAM were tumor size (OR: 3.46, 95% CI: 1.71 - 7.01) and tumor location (OR: 3, 95% CI: 1.03 - 8.72). Similarly, for incidence of cytoplasmic ALCAM were age (OR: 2.56, 95% CI: 1.38 - 4.76) and location of the tumor (OR: 3.23, 95% CI: 1.08 - 9.64). However, the only predictor of membranous ALCAM incidence was lymph node involvement (OR: 0.36, 95% CI: 0.19 - 0.66).
The results of our study suggest preliminary evidence for the potential clinical application of ALCAM as a prognostic biomarker for OSCC which may be the basis for future clinical application, however further studies are recommended.
确定活化白细胞细胞黏附分子（ALCAM）在口腔鳞状细胞癌（OSCC）患者中的发生情况及其预测因素。
这是一项 1997 年至 2015 年期间在德黑兰伊玛目霍梅尼医院就诊的 102 例 OSCC 患者的横断面研究。数据收集工具是一份检查表，其中包括来自患者病历的人口统计学和病理学特征（淋巴结受累、分化、肿瘤大小和肿瘤位置）。为了评估 ALCAM，从存档中准备了新的肿瘤组织样本。最后，使用 STATA14 中的多变量逻辑回归模型确定 ALCAM 的预测因素。
男性和女性的人数（%）分别为 70（68.6）和 32（31.4）。参与者的平均年龄（标准差）为 61.7（15.6）岁。在总样本中，32（38.2）、19（18.6）、36（35.3）和 8（7.8）个样本分别与舌、口腔黏膜、皮肤和嘴唇有关。超过一半的肿瘤分化良好，淋巴结受累，74.5%的肿瘤≥20mm。此外，79.41%的样本总体上 ALCAM 阳性。总体上 ALCAM 发生率的最重要预测因子是肿瘤大小（OR：3.46，95%CI：1.71-7.01）和肿瘤位置（OR：3，95%CI：1.03-8.72）。同样，对于细胞质 ALCAM 的发生率，年龄（OR：2.56，95%CI：1.38-4.76）和肿瘤位置（OR：3.23，95%CI：1.08-9.64）是预测因子。然而，膜性 ALCAM 发生率的唯一预测因子是淋巴结受累（OR：0.36，95%CI：0.19-0.66）。
我们的研究结果初步表明，ALCAM 作为 OSCC 的预后生物标志物具有潜在的临床应用价值，这可能是未来临床应用的基础，但需要进一步研究。
